RSV Paired Antibody
Description
Product Specs
Purified monoclonal IgG2a by protein A chromatography.
Product Science Overview
Human Respiratory Syncytial Virus (hRSV) is a negative-sense single-stranded RNA virus belonging to the genus Pneumovirus. It is a major cause of respiratory infections, particularly in infants, young children, and the elderly. The virus can lead to severe bronchiolitis and pneumonia, making it a significant public health concern.
Mouse models have been extensively used in hRSV research due to their genetic similarities to humans and the availability of various immunological tools. These models help in understanding the pathogenesis of hRSV and evaluating potential therapeutics.
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Rag2 Knockout Mice: One notable model involves Rag2 gene knockout mice, which are deficient in T and B cells. These mice can sustain high viral loads upon intranasal inoculation with hRSV, making them useful for studying long-term infection and pathogenesis . The use of CRISPR/Cas9 technology has enabled the creation of these models, which exhibit severe bronchopneumonia and elevated cytokine levels.
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Immunological Studies: The laboratory mouse is the species of choice for most immunological studies, ranging from simple vaccine testing to intricate dissection of immunopathogenic mechanisms . Although not fully adapted to mice, some strains of hRSV can replicate in the murine respiratory tract and induce specific T and B cell responses. Passive transfer of neutralizing antibodies has shown to be protective and assists in viral clearance.
Monoclonal antibodies targeting hRSV have shown promise in both prophylactic and therapeutic settings. These antibodies can neutralize the virus and prevent its spread within the host. In mouse models, humanized monoclonal antibodies have demonstrated strong antiviral activity, suggesting their potential for clinical use .
Despite the advancements, there are challenges in using mouse models for hRSV research. The semi-permissiveness and short duration of infection in some models limit their application. However, the development of more sophisticated models, such as the Rag2 knockout mice, offers new opportunities for studying hRSV and evaluating novel therapeutics .
