Reovirus Antibody
Description
Product Specs
Product Science Overview
Introduction
Mouse antibodies, also known as murine antibodies, are antibodies derived from mice. These antibodies are widely used in research and therapeutic applications due to their ability to target specific antigens .
Types and Production
There are five antibody isotypes in mice: IgA, IgD, IgE, IgG, and IgM, each with a different heavy chain . Monoclonal antibodies (MAbs) are produced by immunizing mice with a target antigen and then harvesting the antibody-producing cells . These cells are fused with myeloma cells to create hybridomas, which can produce large quantities of the desired antibody .
Human Anti-Mouse Antibody (HAMA) Response
One challenge with using mouse antibodies in humans is the Human Anti-Mouse Antibody (HAMA) response . The human immune system can recognize mouse antibodies as foreign and produce antibodies against them, leading to allergic reactions and reduced efficacy of the treatment . Advances in antibody engineering have led to the development of chimeric and humanized antibodies, which are less likely to trigger the HAMA response .
Applications
Mouse antibodies are used in various diagnostic and therapeutic applications. They are employed in immunoassays, imaging studies, and as treatments for diseases such as cancer and autoimmune disorders . Fully human monoclonal antibodies, produced using transgenic mice or in vitro techniques, are becoming increasingly common due to their reduced immunogenicity .
