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Monoclonal Antibodies

Other Monoclonal Antibodies

Anti Human Lymphocyte

Anti Mouse Cytokine

Anti Human Cytokine

Anti Mouse Lymphocyte

Anti-GST Monoclonal

Anti Viral Monoclonal

Anti Human Heat Shock Protein

Anti Human Enzyme

Product List

NKp46 Antibody

Natural Cytotoxicity Receptor NKp46, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT27837

Source

Appearance

Sterile Filtered colorless solution.

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NME1 Antibody

Non-Metastatic Cells 1, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT27915

Source

Appearance

Sterile filtered colorless solution.

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NPM1 Antibody

Nucleophosmin, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT28003

Source

Appearance

Sterile filtered colorless solution.

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NRAS Antibody

Neuroblastoma RAS Viral Oncogene Homolog, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT28083

Source

Appearance

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OTUB1 Antibody

Ubiquitin Aldehyde Binding 1, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT28182

Source

Appearance

Sterile filtered colorless solution.

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OTUB2 Antibody

Mouse Anti Human Ubiquitin Aldehyde Binding 2

Shipped with Ice Packs

Cat. No.

BT28257

Source

Appearance

Sterile filtered colorless solution.

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p53 Antibody

p53, Mouse Antibody

Monoclonal antibodies are produced by immunizing mouse with full length His-tagged p53 protein.

Shipped with Ice Packs

Cat. No.

BT28337

Source

Appearance

Sterile Filtered solution.

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p53 or TP53 is a cell cycle related transcription factor that promotes transcription of genes that induce cell cycle arrest or apoptosis in response to DNA damage or other cell stresses.
This tumour suppressor gene is mutated in about half of all human cancers.
Recombinant Anti p53 produced in E.Coli is a non-glycosylated, polypeptide chain containing a hexahistidine tag and having a molecular weight of 37 kDa.
The rAp53 is purified by proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT28417

Source

Escherichia Coli.

Appearance

Sterile Filtered clear solution.

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PA2G4 Antibody

Proliferation-associated protein 2G4, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT28497

Source

Appearance

Sterile filtered colorless solution.

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PAIP2 Antibody

Polyadenylate-Binding Protein-Interacting Protein 2, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT28579

Source

Appearance

Sterile Filtered colorless solution.

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Introduction

Definition and Classification

Monoclonal antibodies (mAbs) are laboratory-produced molecules engineered to serve as substitute antibodies that can restore, enhance, or mimic the immune system’s attack on cells. They are produced by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies can be classified based on their source and structure:

Murine mAbs: Derived from mouse cells.
Chimeric mAbs: Contain both human and mouse components.
Humanized mAbs: Mostly human, with only small mouse-derived components.
Human mAbs: Fully human antibodies.

Biological Properties

Monoclonal antibodies exhibit several key biological properties:

Protein Sequence: Identical protein sequences and antigen-binding sites.
Expression Patterns: Produced by B lymphocytes and expressed in hybridoma cells.
Tissue Distribution: Can be designed to target specific tissues or cells, such as cancer cells.

Biological Functions

Monoclonal antibodies play crucial roles in the immune system:

Pathogen Recognition: Bind to specific antigens on pathogens, marking them for destruction.
Immune Response: Enhance the immune system’s ability to fight infections and diseases.
Therapeutic Functions: Used in treating various diseases, including cancer, autoimmune disorders, and infectious diseases.

Modes of Action

Monoclonal antibodies interact with other molecules and cells through various mechanisms:

Binding Partners: Bind to specific antigens on target cells.
Downstream Signaling Cascades: Trigger immune responses by activating immune cells and complement systems.
Effector Functions: Engage Fc receptors on immune cells, leading to cell-mediated cytotoxicity.

Regulatory Mechanisms

The expression and activity of monoclonal antibodies are tightly regulated:

Transcriptional Regulation: Controlled by specific transcription factors that regulate the expression of antibody genes.
Post-Translational Modifications: Undergo modifications such as glycosylation, which can affect their stability and function.

Applications

Monoclonal antibodies have a wide range of applications in biomedical research and medicine:

Diagnostic Tools: Used in assays to detect specific antigens in samples.
Therapeutic Strategies: Employed in the treatment of cancers, autoimmune diseases, and infectious diseases.
Biomedical Research: Serve as tools to study cellular processes and disease mechanisms.

Role in the Life Cycle

Monoclonal antibodies play roles throughout the life cycle:

Development: Used in prenatal diagnostics and treatments.
Aging: Help manage age-related diseases such as cancer and Alzheimer’s.
Disease: Provide targeted therapies for various diseases, improving patient outcomes.