PA2G4 Antibody
Proliferation-associated protein 2G4, Mouse Anti Human
Cat. No.
BT28497
Source
Synonyms
Proliferation-associated protein 2G4, Cell cycle protein
p38-2G4 homolog, hG4-1, ErbB3-binding protein 1, PA2G4, EBP1, p38-2G4.
Appearance
Sterile filtered colorless solution.
Purity
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
Product Specs
Introduction
PA2G4, a member of the peptidase M24C family, acts as an RNA-binding protein with roles in cellular proliferation and differentiation. It participates in ribosome assembly and regulates rRNA processing as a component of pre-ribosomal ribonucleoprotein complexes. Additionally, PA2G4 interacts with ErbB-3, potentially modulating the ErbB-3 signaling pathway by regulating Neuregulin-1 effects. It also functions as a transcriptional co-repressor of androgen receptor-regulated and cell cycle regulatory genes via interactions with histone deacetylases. PA2G4 has been implicated in inhibiting growth and inducing differentiation in human cancer cells. Moreover, it mediates cap-independent translation of specific viral internal ribosomal entry sites (IRESs). PA2G4 associates with mature 28S, 18S, and 5.8S rRNAs, several rRNA precursors, and possibly U3 small nucleolar RNA.
Physical Appearance
Sterile filtered colorless solution.
Formulation
1mg/ml in PBS, pH 7.4, with 10% Glycerol and 0.02% Sodium Azide.
Storage Procedures
Store at 4°C for up to 1 month. For longer durations, store at -20°C. Avoid freeze-thaw cycles.
Stability / Shelf Life
Stable for 12 months at -20°C. Stable for 1 month at 4°C.
Applications
This antibody's specificity and reactivity have been validated through ELISA, Western blot analysis, Flow cytometry, and ICC/IF. However, optimal working dilutions should be determined empirically for each application.
Synonyms
Proliferation-associated protein 2G4, Cell cycle protein
p38-2G4 homolog, hG4-1, ErbB3-binding protein 1, PA2G4, EBP1, p38-2G4.
Purification Method
PA2G4 antibody was purified from mouse ascitic fluids by
protein-A affinity chromatography.
Type
Mouse Anti Human Monoclonal.
Clone
PAT5E7AT.
Immunogen
Anti-human PA2G4 mAb, is
derived from hybridization of mouse F0 myeloma cells with spleen cells from
BALB/c mice immunized with a recombinant human PA2G4 protein 1-394 amino
acids purified from E. coli.
Ig Subclass
Mouse IgG1 heavy chain and k light chain.
Product Science Overview
Introduction
Proliferation-associated protein 2G4 (PA2G4), also known as ErbB3-binding protein 1 (EBP1), is a protein encoded by the PA2G4 gene. This protein plays a crucial role in growth regulation and is involved in various cellular processes, including ribosome assembly and the regulation of rRNA processing .
Gene and Protein Structure
Biological Functions
PA2G4 is involved in several key biological processes:
- Growth Regulation: PA2G4 interacts with the cytoplasmic domain of the ErbB3 receptor, contributing to the transduction of growth regulatory signals .
- Transcriptional Co-repressor: It acts as a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases .
- Ribosome Assembly: PA2G4 is involved in the regulation of intermediate and late steps of rRNA processing, which is essential for ribosome assembly .
Role in Cancer
Mouse Anti-Human PA2G4 Antibody
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