KIR2DS4 Human

Killer Cell Immunoglobulin-Like Receptor, 2 Domains Short Cytoplasmic Tail, 4 Recombinant Human
Cat. No.
BT26479
Source
Escherichia Coli.
Synonyms
Killer cell immunoglobulin-like receptor 2DS4, MHC class I NK cell receptor, Natural killer-associated transcript 8, NKAT-8, P58 natural killer cell receptor clone CL-39, p58 NK receptor, CL-17, CD158 antigen-like family member I, CD158i antigen, KIR2DS4, CD158I, KKA3, NKAT8, KIR1D, KIR412, MGC120019, MGC125315, MGC125317.
Appearance
Sterile filtered colorless solution.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

Recombinant Human KIR2DS4 produced in E.Coli is a single, non-glycosylated polypeptide chain (23-223 aa) containing a total of 202 amino acids and having a molecular mass of 22.2kDa.
The KIR2DS4 is purified by proprietary chromatographic techniques.

Product Specs

Introduction
Killer-cell immunoglobulin-like receptors (KIRs) are proteins found on Natural Killer (NK) cells, which are part of the immune system. KIRs help NK cells decide whether to eliminate a target cell, such as a virally infected or cancerous cell. They do this by interacting with MHC class I molecules on the surface of other cells. Most KIRs are inhibitory, meaning they prevent NK cell activation, while a few are activating. KIR genes are located on chromosome 19 and are highly diverse, resulting in different KIR combinations in individuals. KIR proteins are classified based on their structure and function. KIR2DS4 is an activating KIR that may interact with MHC class I molecules.
Description
Recombinant Human KIR2DS4 is a laboratory-produced protein made using E. coli bacteria. It is a single chain of 202 amino acids without any sugar modifications and has a molecular weight of 22.2kDa. The purity of this protein is greater than 95%, achieved through specific purification methods.
Physical Appearance
A clear, colorless solution that has been sterilized by filtration.
Formulation
The KIR2DS4 protein is provided in a solution containing 20mM Tris-HCl at a pH of 7.5, with a concentration of 1mg/ml.
Stability
For short-term storage (up to 4 weeks), keep at 4°C. For longer periods, store frozen at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for extended storage. Avoid repeated freezing and thawing.
Purity
Purity exceeding 95.0% as assessed by SDS-PAGE analysis.
Synonyms
Killer cell immunoglobulin-like receptor 2DS4, MHC class I NK cell receptor, Natural killer-associated transcript 8, NKAT-8, P58 natural killer cell receptor clone CL-39, p58 NK receptor, CL-17, CD158 antigen-like family member I, CD158i antigen, KIR2DS4, CD158I, KKA3, NKAT8, KIR1D, KIR412, MGC120019, MGC125315, MGC125317.
Source
Escherichia Coli.
Amino Acid Sequence

MEGVHRKPSF LALPGHLVKS EETVILQCWS DVMFEHFLLH REGKFNNTLH LIGEHHDGVS KANFSIGPMM PVLAGTYRCY GSVPHSPYQL SAPSDPLDMV IIGLYEKPSL SAQPGPTVQA GENVTLSCSS RSSYDMYHLS REGEAHERRL PAVRSINGTF QADFPLGPAT HGGTYRCFGS FRDAPYEWSN SSDPLLVSVT GN.

Product Science Overview

Introduction

Killer Cell Immunoglobulin-Like Receptors (KIRs) are a family of type I transmembrane glycoproteins expressed on the surface of natural killer (NK) cells and a subset of T cells. These receptors play a crucial role in the regulation of the immune response by interacting with human leukocyte antigen (HLA) class I molecules. Among the KIR family, KIR2DS4 is a notable member due to its unique structure and function.

Structure and Function

KIR2DS4, also known as Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 4, is a protein-coding gene. The KIR proteins are classified based on the number of extracellular immunoglobulin domains (2D or 3D) and the length of their cytoplasmic tail (short or long). KIR2DS4 has two extracellular immunoglobulin domains and a short cytoplasmic tail, which lacks the immunoreceptor tyrosine-based inhibitory motif (ITIM) that is present in KIR proteins with long cytoplasmic tails .

The absence of ITIM in KIR2DS4 means that it does not transduce inhibitory signals. Instead, it associates with the TYRO protein tyrosine kinase binding protein to transduce activating signals. This makes KIR2DS4 an activating receptor, which plays a role in the activation of NK cells and the subsequent immune response .

Genetic Location and Variability

The KIR genes are located in a cluster on chromosome 19q13.4 within the leukocyte receptor complex (LRC). This region is highly polymorphic, and the gene content of the KIR cluster varies among different haplotypes. Despite this variability, several “framework” genes, including KIR3DL3, KIR3DP1, KIR3DL4, and KIR3DL2, are found in all haplotypes .

Role in Disease

KIR2DS4 has been associated with various diseases due to its role in immune regulation. For instance, it has been linked to rheumatoid arthritis, where the presence of KIR2DS4 may influence the severity and progression of the disease. Additionally, KIR2DS4 has been implicated in the immune response to viral infections and cancer .

Recombinant Human KIR2DS4

Recombinant human KIR2DS4 is a laboratory-produced version of the natural KIR2DS4 protein. It is used in research to study the function of KIR2DS4 and its interactions with other molecules. By using recombinant proteins, scientists can better understand the role of KIR2DS4 in the immune system and its potential as a therapeutic target .

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