IL-6 PAT1H6AT Antibody
Interleukin-6 Clone PAT1H6AT, Mouse Anti Human
Cat. No.
BT8518
Source
Synonyms
IFN-b2, B cell differentiation factor, BCDF, BSF-2, HPGF, HSF, MGI-2, B-cell stimulatory factor 2, Interferon beta-2, Hybridoma growth factor, CTL differentiation factor, CDF, IL-6, HGF.
Appearance
Sterile filtered colorless solution.
Purity
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
Product Specs
Introduction
Interleukin-6 (IL-6) is a multifunctional cytokine with a wide range of biological activities. It plays a crucial role in the final differentiation of B-cells into antibody-secreting cells, supports the growth of myeloma and plasmacytoma cells, induces the differentiation of nerve cells, and stimulates the production of acute-phase reactants in hepatocytes.
Physical Appearance
A clear, colorless solution that has been sterilized by filtration.
Formulation
The antibody is supplied at a concentration of 1 mg/ml in a solution containing phosphate-buffered saline (PBS) at pH 7.4, 10% glycerol, and 0.02% sodium azide.
Storage Procedures
For short-term storage (up to 1 month), the antibody should be kept at 4°C. For long-term storage, it is recommended to store the antibody at -20°C. Repeated freeze-thaw cycles should be avoided.
Stability / Shelf Life
The antibody is stable for 12 months when stored at -20°C and for 1 month when stored at 4°C.
Applications
The IL-6 antibody has been validated for use in various applications, including ELISA, Western blot analysis, flow cytometry, and immunocytochemistry/immunofluorescence (ICC/IF), to ensure its specificity and reactivity. However, it is essential to optimize the antibody concentration for each specific application to achieve optimal results.
Synonyms
IFN-b2, B cell differentiation factor, BCDF, BSF-2, HPGF, HSF, MGI-2, B-cell stimulatory factor 2, Interferon beta-2, Hybridoma growth factor, CTL differentiation factor, CDF, IL-6, HGF.
Purification Method
IL-6 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Type
Mouse Anti Human Monoclonal.
Clone
PAT1H6AT.
Immunogen
Anti-human IL-6, clone PAT1H6AT mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human IL-6 protein 30-212 amino acids purified from E. coli.
Ig Subclass
Mouse IgG2a heavy chain and k light chain.
Product Science Overview
Introduction
Interleukin-6 (IL-6) is a multifunctional cytokine that plays a crucial role in immune responses and inflammation. The Interleukin-6 Clone PAT1H6AT is a monoclonal antibody derived from mouse cells, specifically designed to target and detect human IL-6. This antibody is widely used in biomedical research to study the various roles of IL-6 in physiological and pathological contexts.
Molecular Characteristics
Biological Functions of IL-6
IL-6 is involved in a wide range of biological processes:
- B-cell Differentiation: IL-6 plays an essential role in the final differentiation of B-cells into immunoglobulin-secreting cells.
- Growth Induction: It induces the growth of myeloma and plasmacytoma cells.
- Nerve Cell Differentiation: IL-6 promotes the differentiation of nerve cells.
- Acute Phase Reactants: In hepatocytes, IL-6 induces the production of acute phase reactants .
Applications
Storage and Stability
For optimal stability, the antibody should be stored at -20°C for long-term storage and at 4°C for short-term storage. It is important to avoid freeze-thaw cycles to maintain the antibody’s integrity. The shelf life of the antibody is approximately 12 months when stored at -20°C and 1 month at 4°C .
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