MAPK3 Human
Description
ERK1/MAPK3 is purified by proprietary chromatographic techniques.
Product Specs
For short-term storage (2-4 weeks), the product can be stored at 4°C. For long-term storage, it is recommended to store the product in aliquots at -20°C. Repeated freezing and thawing should be avoided to maintain product stability.
Product Science Overview
MAPK3 is a protein-coding gene located on chromosome 16 in humans. The gene encodes a serine/threonine kinase, which is activated by upstream kinases. Upon activation, MAPK3 translocates to the nucleus, where it phosphorylates nuclear targets . The protein is composed of 379 amino acids and has a molecular weight of approximately 44 kDa .
MAPK3, along with MAPK1 (ERK2), forms part of the MAPK/ERK cascade. This cascade is initiated by various extracellular signals, such as growth factors, cytokines, and environmental stresses. The activation of MAPK3 involves a series of phosphorylation events, leading to its translocation to the nucleus. Once in the nucleus, MAPK3 phosphorylates various transcription factors, thereby regulating gene expression .
The MAPK/ERK pathway, in which MAPK3 plays a pivotal role, is essential for numerous cellular functions. These include:
- Cell Proliferation: MAPK3 promotes cell division by regulating the expression of genes involved in the cell cycle.
- Differentiation: It influences the differentiation of various cell types by modulating specific transcription factors.
- Survival and Apoptosis: MAPK3 can either promote cell survival or induce apoptosis, depending on the cellular context and the nature of the extracellular signals .
