MAPK3 Antibody

Mitogen-Activated Protein Kinase 3 (MAPK3), also known as Extracellular Signal-Regulated Kinase 1 (ERK1), is a crucial component of the MAP kinase signal transduction pathway. This pathway plays a significant role in regulating various cellular processes, including proliferation, differentiation, and cell cycle progression in response to extracellular signals .

MAPK3 is a serine/threonine kinase that is activated by upstream kinases. Upon activation, it translocates to the nucleus where it phosphorylates nuclear targets . This kinase is part of a larger family of MAP kinases, which are involved in transmitting signals from the cell surface to the DNA in the cell nucleus .

MAPK3, along with MAPK1 (ERK2), is essential in the MAPK/ERK cascade. This cascade is initiated by various extracellular signals, including growth factors and stress signals. The activation of MAPK3 leads to the phosphorylation of various downstream targets, which in turn regulate gene expression, mitosis, differentiation, and cell survival .

The mouse anti-human MAPK3 antibody is a monoclonal antibody that specifically binds to the human MAPK3 protein. This antibody is used in various research applications, including Western blotting, immunohistochemistry, and flow cytometry, to study the expression and function of MAPK3 in human cells .

Research on MAPK3 has significant implications for understanding various diseases, including cancer, neurological disorders, and inflammatory diseases. The MAPK/ERK pathway is often dysregulated in cancer, making MAPK3 a potential target for therapeutic intervention . Additionally, studies have shown that mutations in MAPK3 are associated with conditions such as autism spectrum disorder and epilepsy .