Acrp30 Mouse
HEK293 cells.
Acrp30, AdipoQ, GBP-28, APM-1, ACDC.
Greater than 90.0% as determined by SDS-PAGE.
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Description
Acrp30 Mouse Recombinant is a single, glycosylated polypeptide chain containing 230 amino acids (18-247a.a) and having a molecular mass of 24.9kDa (calculated).
Product Specs
Acrp30, AdipoQ, GBP-28, APM-1, ACDC.
HEK293 cells.
EDDVTTTEEL APALVPPPKG TCAGWMAGIP GHPGHNGTPG RDGRDGTPGE KGEKGDAGLL GPKGETGDVG MTGAEGPRGF PGTPGRKGEP GEAAYVYRSA FSVGLETRVT VPNVPIRFTK IFYNQQNHYD GSTGKFYCNI PGLYYFSYHI TVYMKDVKVS LFKKDKAVLF TYDQYQEKNV DQASGSVLLH LEVGDQVWLQ VYGDGDHNGL YADNVNDSTF TGFLLYHDTN.
Product Science Overview
Adiponectin is a member of the complement factor C1q family and consists of several domains: a signal sequence, a non-homologous sequence, a collagen domain, and a globular domain (gAcrp30) . The protein circulates in the plasma and is induced during adipocyte differentiation. Its secretion is stimulated by insulin . Mouse adiponectin shares about 83% amino acid identity with human adiponectin .
Adiponectin has wide-ranging paracrine and endocrine effects on metabolism and inflammation. It promotes adipocyte differentiation, fatty acid catabolism, and insulin sensitivity . The protein is negatively correlated with obesity, type 2 diabetes, and atherogenesis . In metabolic disorders, adiponectin acts as an anti-inflammatory agent, but it can exert pro-inflammatory effects in non-metabolic disorders such as rheumatoid arthritis and inflammatory bowel disease .
Adiponectin is a key regulator of the innate immune system and plays a significant role in the progression of inflammation and metabolic disorders . It modulates the proliferation, plasticity, and polarization of macrophages and monocytes, which are crucial components of the innate immune system . Adiponectin also influences innate-like lymphocytes such as group 2 innate lymphoid cells (ILC2s), natural killer T (NKT) cells, and gamma delta T (γδ T) cells .
Recombinant mouse adiponectin is produced using a mouse myeloma cell line, NS0-derived mouse Adiponectin/Acrp30 protein (Glu18-Asn247), with a C-terminal 6-His tag . The protein is supplied as a 0.2 μm filtered solution in PBS and is typically used in research to study its effects on metabolism and inflammation .
Recombinant mouse adiponectin is used in various research applications, including studies on obesity, diabetes, and cardiovascular diseases. It is also used to investigate the mechanisms underlying its role in regulating innate immunity and inflammation . Understanding the functions and mechanisms of adiponectin can lead to potential therapeutic interventions for metabolic and inflammatory diseases.
