Acrp30 (108-244) Human
Description
Acrp30 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Adiponectin is a protein hormone that plays a crucial role in regulating glucose levels and fatty acid breakdown. It is secreted by adipose tissue and has significant anti-diabetic, anti-atherogenic, and anti-inflammatory properties. The recombinant form of Adiponectin, specifically the fragment spanning amino acids 108-244, is often used in research to study its biological functions and therapeutic potential.
The recombinant human Adiponectin (108-244 a.a.) is a fragment of the full-length protein, which is typically expressed in Escherichia coli. This fragment includes the globular domain of Adiponectin, which is responsible for most of its biological activities. The recombinant protein is usually produced with high purity (>90%) and low endotoxin levels (<1 EU/µg), making it suitable for various biochemical assays and research applications .
Adiponectin is involved in several critical physiological processes:
- Metabolic Regulation: It enhances glucose utilization and fatty acid oxidation by activating AMP-activated protein kinase (AMPK) in the liver and skeletal muscle.
- Anti-inflammatory Effects: Adiponectin antagonizes the effects of tumor necrosis factor-alpha (TNF-α) by inhibiting its expression and activity in various tissues, including the liver and macrophages.
- Cardiovascular Protection: It inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway, which helps in reducing inflammation and atherosclerosis.
- Cell Growth and Angiogenesis: Adiponectin can bind and sequester various growth factors, influencing cell growth, angiogenesis, and tissue remodeling .
Reduced levels of Adiponectin are associated with obesity, insulin resistance, type 2 diabetes, and cardiovascular diseases. Therefore, understanding the mechanisms of Adiponectin and its therapeutic potential is of great interest in medical research. The recombinant form of Adiponectin (108-244 a.a.) is particularly valuable for studying these mechanisms and developing potential treatments for metabolic disorders .
