Acrp30 Human, Sf9
Adiponectin, C1Q And Collagen Domain Containing, Adipose Most Abundant Gene Transcript 1 Protein, Adipocyte Complement-Related 30 KDa Protein, 30 KDa Adipocyte Complement-Related Protein, ACRP30, APM-1, GBP28, ACDC, APM1, Adipocyte, C1q And Collagen Domain-Containing Protein, Adipocyte, C1Q And Collagen Domain Containing, Adipose Most Abundant Gene Transcript 1, Adipose Specific Collagen-Like Factor, Gelatin-Binding Protein 28, Gelatin-Binding Protein, Adiponectin Precursor, Adiponectin, ADIPQTL1, ADPN, 30 kDa adipocyte complement-related protein, dipocyte complement-related 30 kDa protein, ACRP30, Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein.
Description
Acrp30 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 146 amino acids (106-242a.a.) and having a molecular mass of 16.9kDa. (Molecular size on SDS-PAGE will appear at approximately 13.5-18kDa). Acrp30 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
Adiponectin, C1Q And Collagen Domain Containing, Adipose Most Abundant Gene Transcript 1 Protein, Adipocyte Complement-Related 30 KDa Protein, 30 KDa Adipocyte Complement-Related Protein, ACRP30, APM-1, GBP28, ACDC, APM1, Adipocyte, C1q And Collagen Domain-Containing Protein, Adipocyte, C1Q And Collagen Domain Containing, Adipose Most Abundant Gene Transcript 1, Adipose Specific Collagen-Like Factor, Gelatin-Binding Protein 28, Gelatin-Binding Protein, Adiponectin Precursor, Adiponectin, ADIPQTL1, ADPN, 30 kDa adipocyte complement-related protein, dipocyte complement-related 30 kDa protein, ACRP30, Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein.
ADPEGAYVYR SAFSVGLETY VTIPNMPIRF TKIFYNQQNH YDGSTGKFHC NIPGLYYFAY HITVYMKDVK VSLFKKDKAM LFTYDQYQEN NVDQASGSVL LHLEVGDQVW LQVYGEGERN GLYADNDNDS TFTGFLLYHD HHHHHH.
Product Science Overview
Adiponectin, also known as Acrp30, AdipoQ, and GBP28, is a protein hormone predominantly secreted by adipose tissue. It plays a crucial role in regulating metabolic processes such as glucose regulation and fatty acid oxidation. The recombinant form of adiponectin, produced in Sf9 Baculovirus cells, is a valuable tool for research and therapeutic applications.
Adiponectin is a glycosylated polypeptide chain containing 146 amino acids (106-242 a.a.) with a molecular mass of approximately 16.9 kDa . The protein is expressed with a 6 amino acid His tag at the C-terminus and purified using proprietary chromatographic techniques . The modular structure of adiponectin comprises an N-terminal collagenous domain followed by a C-terminal globular domain .
Adiponectin is involved in various physiological processes, including:
- Energy Homeostasis: It helps regulate energy balance by enhancing insulin sensitivity and promoting fatty acid oxidation .
- Insulin Sensitivity: Adiponectin improves insulin sensitivity, making it a key player in glucose metabolism .
- Hormonal Processes: It influences hormonal activities related to metabolism .
- Fatty Acid Metabolism: Adiponectin promotes the breakdown of fatty acids, contributing to lipid metabolism .
Decreased levels of adiponectin are associated with several metabolic disorders, including:
- Insulin Resistance: Low adiponectin levels are linked to insulin resistance, a hallmark of type 2 diabetes .
- Obesity: Individuals with obesity often exhibit reduced adiponectin levels, which can contribute to metabolic complications .
- Cardiovascular Diseases: Adiponectin has anti-inflammatory properties and can inhibit endothelial NF-kappa-B signaling, reducing the risk of cardiovascular diseases .
Adiponectin’s role in metabolic regulation makes it a promising candidate for therapeutic applications. Potential areas of research and treatment include:
- Metabolic Disorders: Enhancing adiponectin levels could improve insulin sensitivity and glucose metabolism in individuals with type 2 diabetes and obesity .
- Cardiovascular Health: Adiponectin’s anti-inflammatory properties may help mitigate the risk of cardiovascular diseases .
- Inflammatory Responses: By inhibiting TNF-alpha-induced expression of endothelial adhesion molecules, adiponectin may play a role in controlling inflammatory responses .
