TNFRSF14 Human, His
HVEM Human Recombinant, His Tag
Cat. No.
BT27893
Source
E.coli.
Synonyms
Tumor Necrosis Factor Receptor Superfamily Member 14, HVEM, TR2, Herpes Virus Entry Mediator A, Tumor Necrosis Factor Receptor-Like 2, Herpesvirus Entry Mediator, HVEA, ATAR, CD270, LIGHTR, CD40-Like Protein, Tumor Necrosis Factor Receptor-Like Gene2.
Appearance
Sterile filtered colorless solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
TNFRSF14 Human Recombinant produced in E. Coli is a single, glycosylated polypeptide chain containing 187 amino acids (39-202) and having a molecular mass of 19.7kDa.
TNFRSF14 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
TNFRSF14, a member of the TNF receptor superfamily, is a type I transmembrane protein. It is expressed in peripheral blood T cells, B cells, monocytes, and various tissues with abundant lymphoid cells. TNFRSF14 acts as a co-stimulatory factor for lymphoid cell activation and helps defend against herpesvirus infections. It also promotes T cell proliferation and induces apoptosis in various tumor cells.
Description
Recombinant human TNFRSF14, produced in E. Coli, is a single glycosylated polypeptide chain containing 187 amino acids (39-202) with a molecular weight of 19.7 kDa. It consists of the TNFRSF14 protein fused to a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
Colorless, sterile-filtered solution.
Formulation
The TNFRSF14 solution is provided at a concentration of 0.5 mg/mL in a buffer consisting of 20 mM Tris-HCl (pH 8.0), 0.1 M NaCl, and 10% glycerol.
Stability
For short-term storage (2-4 weeks), keep at 4°C. For longer storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity is greater than 85% as determined by SDS-PAGE analysis.
Synonyms
Tumor Necrosis Factor Receptor Superfamily Member 14, HVEM, TR2, Herpes Virus Entry Mediator A, Tumor Necrosis Factor Receptor-Like 2, Herpesvirus Entry Mediator, HVEA, ATAR, CD270, LIGHTR, CD40-Like Protein, Tumor Necrosis Factor Receptor-Like Gene2.
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSLPSCKED EYPVGSECCP KCSPGYRVKE ACGELTGTVC EPCPPGTYIA HLNGLSKCLQ CQMCDPAMGL RASRNCSRTE NAVCGCSPGH FCIVQDGDHC AACRAYATSS PGQRVQKGGT ESQDTLCQNC PPGTFSPNGT LEECQHQTKC SWLVTKAGAG TSSSHWV.
Product Science Overview
Structure and Expression
The recombinant human HVEM protein is typically expressed in HEK293 cells and includes a polyhistidine (His) tag at the C-terminus for purification purposes . The extracellular domain (ECD) of HVEM, which spans from Met1 to Val202, is the primary region used in recombinant protein production . The recombinant protein has a predicted molecular weight of approximately 19 kDa, but due to glycosylation, it appears as 33-38 kDa on SDS-PAGE under reducing conditions .
Function and Ligands
Applications
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