TNFRSF14 Mouse
Sf9, Baculovirus cells.
Tumor Necrosis Factor Receptor Superfamily Member 14, HVEM, TR2, Herpes Virus Entry Mediator A, Tumor Necrosis Factor Receptor-Like 2, Herpesvirus Entry Mediator, HVEA, ATAR, CD270, LIGHTR, CD40-Like Protein, Tumor Necrosis Factor Receptor-Like Gene2.
Greater than 90.0% as determined by SDS-PAGE.
Description
TNFRSF14 Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 407 amino acids (39-206 aa) and having a molecular mass of 45.3kDa.
TNFRSF14 is fused to a 239 amino acid hIgG-His-Tag at C-terminus and purified by proprietary chromatographic techniques.
Product Specs
Tumor Necrosis Factor Receptor Superfamily Member 14, HVEM, TR2, Herpes Virus Entry Mediator A, Tumor Necrosis Factor Receptor-Like 2, Herpesvirus Entry Mediator, HVEA, ATAR, CD270, LIGHTR, CD40-Like Protein, Tumor Necrosis Factor Receptor-Like Gene2.
Sf9, Baculovirus cells.
QPSCRQEEFL VGDECCPMCN PGYHVKQVCS EHTGTVCAPC PPQTYTAHAN GLSKCLPCGV
CDPDMGLLTW QECSSWKDTV CRCIPGYFCE NQDGSHCSTC LQHTTCPPGQ RVEKRGTHDQ
DTVCADCLTG TFSLGGTQEE CLPWTNCSAF QQEVRRGTNS TDTTCSSQLE PKSCDKTHTC
PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN
AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP
QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL
YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG KHHHHHH
Product Science Overview
Herpesvirus entry mediator (HVEM), also known as Tumor Necrosis Factor Receptor Superfamily Member 14 (TNFRSF14), is a type I transmembrane protein that belongs to the TNF-receptor superfamily. HVEM is expressed on various immune cells, including T and B cells, natural killer (NK) cells, monocytes, and neutrophils .
HVEM is composed of an extracellular domain, a transmembrane domain, and a cytoplasmic domain. The extracellular domain of HVEM interacts with several ligands, including LIGHT (TNFSF14), B and T lymphocyte attenuator (BTLA), and CD160. These interactions play crucial roles in immune regulation by modulating T cell activation, proliferation, and cytokine production .
Recombinant Mouse HVEM is a laboratory-produced version of the HVEM protein, specifically designed for research purposes. It is typically expressed in HEK293 cells and purified to high levels of purity (>90%) as determined by SDS-PAGE. The recombinant protein is often tagged with His and Fc regions to facilitate purification and detection .
Recombinant Mouse HVEM retains its biological activity and can bind to its ligands, such as BTLA, in functional assays. This binding ability is often measured using techniques like enzyme-linked immunosorbent assay (ELISA). The recombinant protein is used in various research applications, including studies on immune regulation, cancer immunotherapy, and viral entry mechanisms .
- Immune Regulation: HVEM plays a critical role in modulating immune responses. Studies using recombinant HVEM help in understanding the mechanisms of T cell activation and inhibition, which are essential for developing new immunotherapies.
- Cancer Research: HVEM is overexpressed in certain tumors and is associated with poor prognosis. Research involving recombinant HVEM aims to develop targeted therapies that can block HVEM interactions and enhance anti-tumor immunity .
- Viral Entry: HVEM serves as an entry receptor for herpesviruses. Recombinant HVEM is used to study the mechanisms of viral entry and to develop antiviral strategies .
