SNCA Antibody
Alpha-Synuclein, Mouse Anti Human
Cat. No.
BT346
Source
Synonyms
Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, PD1, PARK1, PARK4, MGC110988, α-Synuclein, SNCA.
Appearance
Sterile Filtered colorless solution.
Purity
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
Product Specs
Introduction
α-Synuclein (amino acids 1-140) is an acidic neuronal protein of 140 amino acids that exhibits high heat resistance. It exists in a natively unfolded state, primarily characterized by an extended structure with random coils. Studies have implicated α-synuclein in the pathogenesis of Parkinson's disease and other related neurodegenerative disorders. Additionally, recent research suggests its crucial role as a regulatory component in neuronal vesicular transport. Furthermore, evidence indicates that α-synuclein possesses chaperone activity, which is compromised upon removal of its C-terminal acidic tail (amino acids 96-140).
Physical Appearance
Sterile Filtered colorless solution.
Formulation
1 mg/ml in PBS, pH 7.4, with 0.1% Sodium Azide.
Storage Procedures
For storage up to 1 month, maintain at 4°C. For longer-term storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Stability / Shelf Life
Stable for 12 months at -20°C and 1 month at 4°C.
Applications
The α-Synuclein antibody has undergone testing through ELISA and Western blot analysis to ensure its specificity and reactivity. However, due to variations in applications, it is recommended to titrate the reagent for optimal results in each specific investigation. For Western blot analysis, a dilution range of 1:500 to 1:2,000 is advised. This α-Synuclein antibody specifically targets the NAC domain (amino acids 61-95) of α-synuclein, with a recommended starting dilution of 1:1,000.
Synonyms
Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, PD1, PARK1, PARK4, MGC110988, α-Synuclein, SNCA.
Purification Method
α-Synuclein antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Type
Mouse Anti Human Monoclonal.
Clone
P5C2AT.
Immunogen
Anti-human α-Synuclein mAb is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human α -Synuclein amino acids 61-95 purified from E. coli.
Ig Subclass
Mouse IgG1 heavy chain and κ light chain.
Product Science Overview
Role in Neurodegenerative Diseases
Research has shown that mutations in the alpha-synuclein gene are linked to familial forms of Parkinson’s disease. These mutations can lead to the misfolding and aggregation of alpha-synuclein, forming insoluble fibrils that contribute to the formation of Lewy bodies. The accumulation of these aggregates is believed to disrupt normal cellular functions, leading to neuronal death and the progression of neurodegenerative diseases .
Mouse Anti-Human Alpha-Synuclein Antibodies
Applications in Research
Mouse anti-human alpha-synuclein antibodies are widely used in research to:
- Detect alpha-synuclein in tissue samples through techniques such as Western blotting, immunohistochemistry, and immunofluorescence.
- Study the distribution and localization of alpha-synuclein in the brain and other tissues.
- Investigate the role of alpha-synuclein in the pathogenesis of neurodegenerative diseases.
- Develop potential therapeutic strategies targeting alpha-synuclein aggregation and toxicity .
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