SNCA Mouse

Alpha-Synuclein Mouse Recombinant
Cat. No.
BT9909
Source
Escherichia Coli.
Synonyms
Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, PD1, PARK1, PARK4, MGC110988, α-Synuclein, SNCA, Syn, SNCA.
Appearance
Sterile filtered colorless solution.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

SNCA Recombinant Mouse produced in E.Coli is a single, non-glycosylated polypeptide chain containing 140 amino acids (1-140 a.a.) and having a molecular mass of 14.4 kDa. The SNCA is purified by proprietary chromatographic techniques.

Product Specs

Introduction
Alpha-synuclein (a-synuclein), a 140-amino acid neuronal protein, exhibits high heat resistance and an intrinsically disordered structure primarily composed of random coils. It has been implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders. Furthermore, a-synuclein plays a crucial role in regulating vesicular transport within neuronal cells and possesses chaperone activity, which is diminished upon removal of its C-terminal acidic tail (amino acids 96-140).
Description
Recombinant Mouse SNCA, expressed in E. coli, is a single, non-glycosylated polypeptide chain encompassing amino acids 1-140. With a molecular weight of 14.4 kDa, this protein undergoes purification using proprietary chromatographic techniques.
Physical Appearance
A clear, colorless solution, sterile-filtered.
Formulation
The SNCA protein is formulated in a buffer consisting of 20mM Tris-HCl (pH 7.5) and 10% glycerol.
Stability
For short-term storage (2-4 weeks), keep at 4°C. For extended periods, store frozen at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Repeated freezing and thawing should be avoided.
Purity
Purity exceeds 95.0% as determined by SDS-PAGE analysis.
Synonyms
Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, PD1, PARK1, PARK4, MGC110988, α-Synuclein, SNCA, Syn, SNCA.
Source
Escherichia Coli.
Amino Acid Sequence
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP GSEAYEMPSE EGYQDYEPEA.

Product Science Overview

Structure and Function

Alpha-synuclein is composed of 140 amino acids and is known for its conformational flexibility . It plays several crucial roles in synaptic activity, including the regulation of synaptic vesicle trafficking and neurotransmitter release . As a monomer, alpha-synuclein enhances vesicle priming, fusion, and dilation of exocytotic fusion pores by increasing local calcium release from microdomains . Additionally, in its multimeric membrane-bound state, it acts as a molecular chaperone, assisting in the folding of synaptic fusion components known as SNAREs (Soluble NSF Attachment Protein REceptors) at the presynaptic plasma membrane .

Pathological Role

Alpha-synuclein is notably involved in the pathogenesis of several neurodegenerative diseases, collectively known as synucleinopathies. These include Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) . The aggregation of alpha-synuclein in the brain is a hallmark of these diseases and is associated with the loss of nigral dopaminergic neurons, leading to motor symptoms characteristic of parkinsonism . However, it is important to note that alpha-synuclein pathology can occur independently of parkinsonism, as it is also observed in asymptomatic senescent brains .

Recombinant Alpha-Synuclein

Recombinant alpha-synuclein (mouse) is a full-length protein expressed in Escherichia coli, with a purity greater than 95% . This recombinant protein is biologically active and suitable for various applications, including SDS-PAGE and functional studies . It is used extensively in research to study the role of alpha-synuclein in synaptic activity and its involvement in neurodegenerative diseases.

Research and Therapeutic Implications

Given its central role in synucleinopathies, alpha-synuclein is a key target for research aimed at understanding and treating these diseases. Despite its importance, there is currently no consensus on reliable markers for defining toxic pathogenic alpha-synuclein aggregates in postmortem human brain tissue . As such, there is an urgent need to develop a panel of antibodies and animal models for studying synucleinopathies .

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