SNCA Human
Alpha Synuclein Human Recombinant
Cat. No.
BT9839
Source
Escherichia Coli.
Synonyms
Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, PD1, PARK1, PARK4, MGC110988, a-Synuclein, SNCA.
Appearance
Sterile filtered colorless solution.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
a-Synuclein Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain of 140 amino acids having a molecular mass of 14.4kDa (Real molecular weight on SDS-PAGE will be shift up).
The Recombinant Human a-Synuclein is purified by proprietary chromatographic techniques.
The Recombinant Human a-Synuclein is purified by proprietary chromatographic techniques.
Product Specs
Introduction
Alpha-synuclein (a-synuclein), a 140-amino acid neuronal protein, plays a role in Parkinson's disease and related neurodegenerative disorders. This protein exhibits heat resistance, an extended unfolded structure with random coils, and potential involvement in vesicular transport regulation. Studies indicate its chaperone activity, which is influenced by the C-terminal acidic tail (amino acids 96-140).
Description
Recombinant Human a-Synuclein, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 140 amino acids. It has a molecular mass of 14.4 kDa. Note: The actual molecular weight observed on SDS-PAGE might be higher. The protein undergoes purification using proprietary chromatographic methods.
Physical Appearance
Clear, colorless solution that has been sterilized by filtration.
Formulation
The protein solution (1 mg/ml) is supplied in a buffer containing 20 mM Tris-HCl (pH 7.5), 0.1 M NaCl, and 1 mM MgCl2.
Stability
For short-term storage (up to 2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to freeze the protein at -20°C. Adding a carrier protein such as HSA or BSA (0.1%) can further enhance stability during long-term storage. Avoid repeated freezing and thawing.
Purity
The purity is determined to be greater than 95.0% using SDS-PAGE analysis.
Synonyms
Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, PD1, PARK1, PARK4, MGC110988, a-Synuclein, SNCA.
Source
Escherichia Coli.
Amino Acid Sequence
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA.
Product Science Overview
Structural Characteristics
Biological Functions
Alpha-synuclein is involved in several critical biological processes:
Pathological Implications
Alpha-synuclein is a major component of Lewy bodies, which are pathological hallmarks of several neurodegenerative diseases, collectively known as synucleinopathies. These include:
Recombinant Alpha Synuclein
Research and Clinical Relevance
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