SNAP23 Human

SNAP23 is structurally and functionally similar to SNAP25, another member of the SNARE family. It binds tightly to multiple syntaxins and synaptobrevins/VAMPs, forming a complex that serves as a binding site for the general membrane fusion machinery . This protein is essential for the high-affinity receptor involved in the docking and fusion of transport vesicles .

Unlike SNAP25, which is predominantly found in the brain, SNAP23 is ubiquitously expressed in various tissues, including the plasma membrane and other intracellular membranes . This widespread expression allows SNAP23 to facilitate exocytotic membrane fusion in most cells that do not express SNAP25 .

SNAP23 is involved in several critical cellular processes, including:

• Vesicular Transport: It regulates the docking and fusion of transport vesicles, ensuring the proper delivery of cargo within the cell .
• Membrane Fusion: SNAP23 plays a vital role in the fusion of vesicles with target membranes, a process essential for neurotransmitter release, hormone secretion, and other cellular functions .

Recombinant human SNAP23 protein is produced using various expression systems, such as Escherichia coli, to achieve high purity and functionality . This recombinant protein is used in research to study the mechanisms of vesicular transport and membrane fusion, as well as in the development of diagnostic and therapeutic applications .

Mutations or dysregulation of SNAP23 have been associated with several diseases, including:

• Osteogenesis Imperfecta, Type VIII: A genetic disorder characterized by brittle bones .
• Griscelli Syndrome: A rare genetic condition affecting pigmentation and immune function .