SCF Canine

SCF is essential for the survival, proliferation, and differentiation of hematopoietic stem cells, which are the precursors to all blood cell types. It also supports the migration and proliferation of mesenchymal stem cells (MSCs), which can differentiate into various cell types such as bone, cartilage, and fat cells . This makes SCF a vital component in regenerative medicine and cellular therapies.

The recombinant canine SCF is produced in E. coli and purified using proprietary chromatographic techniques to ensure high purity and activity . The protein is typically lyophilized from a filtered solution in phosphate-buffered saline (PBS) and can be reconstituted in sterile PBS for use in various applications .

Recombinant canine SCF is widely used in research to study stem cell biology, hematopoiesis, and tissue regeneration. It is also employed in preclinical and clinical settings to enhance the efficacy of stem cell therapies. For instance, SCF has been shown to support the migration and proliferation of canine mesenchymal stem cells, making it a valuable tool in veterinary regenerative medicine .

The stability and storage conditions for recombinant canine SCF are critical to maintaining its activity. The lyophilized protein should be stored at -20 to -70°C and reconstituted in sterile conditions to prevent contamination. Once reconstituted, the protein can be stored at 2 to 8°C for up to one month or at -20 to -70°C for up to three months under sterile conditions .