Omentin Antibody

Omentin, also known as omentin-1, is a novel adipokine predominantly expressed in visceral adipose tissue (VAT). It plays a crucial role in various metabolic processes and has been linked to obesity, insulin resistance, and cardiovascular diseases . Omentin-1 is known for its anti-inflammatory and insulin-sensitizing properties, making it a significant molecule in metabolic research .

Omentin-1 enhances insulin-mediated glucose uptake in adipocytes, contributing to improved insulin sensitivity . It also exhibits anti-inflammatory effects by inhibiting the expression of pro-inflammatory cytokines such as TNF-α and reducing oxidative stress . Additionally, omentin-1 promotes vasodilation and revascularization, which are beneficial for cardiovascular health .

Research has shown that omentin-1 levels are decreased in individuals with obesity, insulin resistance, and type 2 diabetes . Lower levels of omentin-1 have also been observed in patients with polycystic ovary syndrome (PCOS) and metabolic dysfunction-associated steatotic liver disease (MASLD) . These findings suggest that omentin-1 plays a protective role against metabolic and cardiovascular diseases.

The mouse anti-human omentin antibody is a monoclonal antibody specifically designed to target and bind to human omentin-1. This antibody is commonly used in research to study the expression and regulation of omentin-1 in various tissues and disease states . It is utilized in techniques such as Western blotting, immunohistochemistry, and enzyme-linked immunosorbent assays (ELISA) to detect and quantify omentin-1 levels .

The mouse anti-human omentin antibody has been instrumental in advancing our understanding of omentin-1’s role in metabolic diseases. For instance, studies using this antibody have demonstrated that insulin and glucose can downregulate omentin-1 expression in adipose tissue . Additionally, research has shown that omentin-1 supplementation can reduce inflammation and oxidative stress in vitro and ex vivo models .