NUDT16 Human
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Description
NUDT16 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
MGSSHHHHHH SSGLVPRGSH MAGARRLELG EALALGSGWR HACHALLYAP DPGMLFGRIP LRYAILMQMR FDGRLGFPGG FVDTQDRSLE DGLNRELREE LGEAAAAFRV ERTDYRSSHV GSGPRVVAHF YAKRLTLEEL LAVEAGATRA KDHGLEVLGL VRVPLYTLRD GVGGLPTFLE NSFIGSAREQ LLEALQDLGL LQSGSISGLK IPAHH
Product Science Overview
NUDT16 is a single, non-glycosylated polypeptide chain consisting of 215 amino acids . It is produced in Escherichia coli (E. coli) and purified through proprietary chromatographic techniques . The protein plays a crucial role in the metabolism of nucleotides, particularly in the decapping of U8 small nucleolar RNA (snoRNA), which is essential for the proper processing and maturation of ribosomal RNA (rRNA).
NUDT16 is involved in several critical cellular processes, including:
- RNA Processing: By decapping U8 snoRNA, NUDT16 ensures the correct processing of rRNA, which is vital for ribosome biogenesis and protein synthesis.
- Nucleotide Metabolism: It hydrolyzes various nucleoside diphosphates, thereby regulating the levels of these molecules within the cell.
- Stress Response: NUDT16 activity is linked to cellular responses to oxidative stress, as it helps in the removal of potentially harmful oxidized nucleotides.
The recombinant form of NUDT16 is widely used in research to study its enzymatic activity, substrate specificity, and role in cellular metabolism. Understanding the function of NUDT16 can provide insights into the mechanisms of RNA processing and the cellular response to oxidative stress. Additionally, it has potential applications in the development of therapeutic strategies for diseases related to nucleotide metabolism and RNA processing.
