MIP 1a Mouse
Small inducible cytokine A3, CCL3, Macrophage inflammatory protein 1-alpha, MIP-1-alpha, Tonsillar lymphocyte LD78 alpha protein, G0/G1 switch regulatory protein 19-1, G0S19-1 protein, SIS-beta, PAT 464.1, chemokine (C-C motif) ligand 3, MIP1A, SCYA3, G0S19-1, LD78ALPHA, TY-5, SIS-alpha, L2G25B.
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Description
The MIP-1a is purified by proprietary chromatographic techniques.
Product Specs
Small inducible cytokine A3, CCL3, Macrophage inflammatory protein 1-alpha, MIP-1-alpha, Tonsillar lymphocyte LD78 alpha protein, G0/G1 switch regulatory protein 19-1, G0S19-1 protein, SIS-beta, PAT 464.1, chemokine (C-C motif) ligand 3, MIP1A, SCYA3, G0S19-1, LD78ALPHA, TY-5, SIS-alpha, L2G25B.
Product Science Overview
Macrophage Inflammatory Protein-1 Alpha (MIP-1α), also known as CCL3, is a chemokine that plays a crucial role in the immune response. It is secreted by macrophages and other cell types and is involved in various biological processes, including inflammation, wound healing, and immune cell recruitment.
MIP-1α/CCL3 was first discovered by Stephen D. Wolpe in 1988 . It belongs to the CC subfamily of chemokines, which are characterized by two adjacent cysteine residues near their amino terminus. The protein is also known by several other names, including C-C motif chemokine 3, Heparin-binding chemotaxis protein, and Small-inducible cytokine A3 .
MIP-1α/CCL3 is a multifunctional peptide that performs various biological functions:
- Recruitment of Inflammatory Cells: It attracts macrophages, lymphocytes, and eosinophils to sites of inflammation via the CCR1 or CCR5 receptors .
- Wound Healing: It plays a role in the wound healing process by recruiting cells necessary for tissue repair .
- Bone Resorption: MIP-1α/CCL3 activates bone resorption cells and directly induces bone destruction, making it significant in conditions involving bone resorption .
- Immune Response: It maintains the effector immune response and has strong HIV-suppressive activity .
MIP-1α/CCL3 is associated with various inflammatory diseases and conditions that exhibit bone resorption, such as:
- Periodontitis: Elevated levels of MIP-1α/CCL3 are found in patients with periodontitis, indicating its role in the disease’s pathogenesis .
- Multiple Myeloma: The protein is involved in the bone destruction seen in multiple myeloma .
- Rheumatoid Arthritis: MIP-1α/CCL3 contributes to the inflammatory processes in rheumatoid arthritis .
- Sjögren Syndrome: It is also implicated in the pathogenesis of Sjögren syndrome .
Recombinant Mouse MIP-1α/CCL3 is a full-length protein expressed in HEK 293 cells. It is used in various research applications, including high-performance liquid chromatography (HPLC), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), and mass spectrometry (MS) . The recombinant protein is highly pure, with a purity level of ≥95% and an endotoxin level of ≤0.005 EU/µg .
