IL 21 Mouse

IL-21 is a four α-helix bundle cytokine closely related to IL-2, IL-7, and IL-15 . The functional receptor for IL-21 is composed of the IL-21 receptor and the common γ-chain, which is expressed on various hematopoietic cells including T, B, NK, and dendritic cells . This receptor composition allows IL-21 to exert pleiotropic effects on both cellular and humoral immune responses .

IL-21 plays a crucial role in the regulation of immune responses. It stimulates the proliferation of lymphocytes, enhances the cytotoxicity of CD8+ T cells and NK cells, and promotes the differentiation of B cells into plasma cells . Additionally, IL-21 is involved in the differentiation of naive CD4+ T cells towards T helper 17 (TH17) cells and follicular T helper (TFH) cells . These functions make IL-21 an important cytokine in both innate and adaptive immunity.

Recombinant mouse IL-21 is a protein optimized for use in cell culture, differentiation studies, and functional assays . It is typically produced in E. coli and purified to high standards, with purities greater than 95% and endotoxin levels below 0.1 ng/μg . The recombinant protein is used in various research applications, including:

• In vitro differentiation of naive CD4+ T cells towards TH17 and TFH cells .
• In vitro expansion of CD8+ T cells and enhancement of cytotoxic T cell function .
• Study of NK cell development and function .
• Investigation of IL-21–mediated molecular signaling pathways .

IL-21 has been proposed to have significant roles in anti-tumor activity and the development of autoimmune diseases . Its ability to modulate immune responses makes it a potential therapeutic target for various conditions, including cancer and autoimmune disorders.