IL21R Human
Description
IL21R shows multiple bands between 28-40kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Interleukin-21 receptor (IL-21R) is a type I cytokine receptor that plays a crucial role in the regulation of the immune system. It is primarily involved in the signaling pathways of interleukin-21 (IL-21), a cytokine that influences the function of various immune cells, including T cells, B cells, and natural killer (NK) cells.
The IL-21 receptor is encoded by the IL21R gene located on chromosome 16 in humans. The receptor is a single-pass type I membrane protein, which means it spans the cell membrane once. It belongs to the type I cytokine receptor family and the type 4 subfamily . The receptor has an extracellular domain, a transmembrane domain, and an intracellular domain that is involved in signal transduction.
IL-21R, in conjunction with its ligand IL-21, plays a significant role in the regulation of the immune response. It is involved in the proliferation and differentiation of T cells and B cells, enhancing the cytotoxic activity of NK cells, and promoting the production of immunoglobulins by B cells . The receptor is also implicated in the regulation of inflammatory responses and has been studied for its role in autoimmune diseases and cancer.
IL-21R is expressed on a variety of immune cells, including T cells, B cells, NK cells, and dendritic cells. Its expression is tightly regulated and can be induced by various stimuli, including other cytokines and antigenic stimulation . The receptor is predominantly found in lymphoid tissues such as the spleen, thymus, and lymph nodes, but it can also be expressed in non-lymphoid tissues under certain conditions.
Recombinant human IL-21R is produced using various expression systems, including E. coli and mammalian cells. The recombinant protein is often tagged with a polyhistidine tag to facilitate purification and is available in both carrier-free and carrier-containing formulations . The recombinant receptor is used in research to study its biological functions, signaling pathways, and potential therapeutic applications.
Recombinant IL-21R is a valuable tool in immunological research. It is used to investigate the signaling mechanisms of IL-21 and its receptor, to study the effects of IL-21R activation on immune cell function, and to develop potential therapeutic strategies for diseases such as cancer, autoimmune disorders, and infectious diseases . The receptor is also used in the development of monoclonal antibodies and other biologics targeting IL-21R for therapeutic purposes.
