IL 1 beta Porcine

IL-1β is initially synthesized as a 31 kDa inactive precursor known as pro-IL-1β. This precursor accumulates in the cytosol and requires cleavage by caspase-1 to become an active 17 kDa protein . The active form of IL-1β is involved in various physiological processes, including:

• Inflammatory Response: IL-1β is a key mediator of inflammation, promoting the expression of adhesion molecules on endothelial cells and the production of other proinflammatory cytokines.
• Fever Induction: It acts on the hypothalamus to induce fever, a common response to infection.
• Tissue Repair: IL-1β plays a role in tissue repair and regeneration by promoting the proliferation and differentiation of various cell types.

Recombinant IL-1β is produced using genetic engineering techniques. The gene encoding IL-1β is inserted into an expression system, such as E. coli, which then produces the protein. This recombinant protein is purified and used for various research and therapeutic purposes.

Porcine IL-1β shares a high degree of similarity with human IL-1β, making it a valuable model for studying the cytokine’s function and potential therapeutic applications. Recombinant porcine IL-1β is used in veterinary medicine and research to understand its role in swine health and disease.

Recombinant IL-1β has several applications in research and medicine:

• Immunology Research: It is used to study the mechanisms of inflammation and immune response.
• Drug Development: IL-1β inhibitors are being developed as potential treatments for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
• Veterinary Medicine: Recombinant porcine IL-1β is used to study and treat inflammatory conditions in swine.