IL6R Mouse
IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130, gp130, Oncostatin-M receptor subunit alpha,CD130.
Description
IL6R is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
| This IL-6R protein solution has a concentration of 1 mg/ml and contains phosphate-buffered saline (pH 7.4) and 10% glycerol. |
IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130, gp130, Oncostatin-M receptor subunit alpha,CD130.
| QLLEPCGYIY PEFPVVQRGS NFTAICVLKE ACLQHYYVNA SYIVWKTNHA AVPREQVTVI NRTTSSVTFT DVVLPSVQLT CNILSFGQIE QNVYGVTMLS GFPPDKPTNL TCIVNEGKNM LCQWDPGRET YLETNYTLKS EWATEKFPDC QSKHGTSCMV SYMPTYYVNI EVWVEAENAL GKVSSESINF DPVDKVKPTP PYNLSVTNSE ELSSILKLSW VSSGLGGLLD LKSDIQYRTK DASTWIQVPL EDTMSPRTSF TVQDLKPFTE YVFRIRSIKD SGKGYWSDWS EEASGTTYED RPSRPPSFWY KTNPSHGQEY RSVRLIWKAL PLSEANGKIL DYEVILTQSK SVSQTYTVTG TELTVNLTND RYVASLAARN KVGKSAAAVL TIPSPHVTAA YSVVNLKAFP KDNLLWVEWT PPPKPVSKYI LEWCVLSENA PCVEDWQQED ATVNRTHLRG RLLESKCYQI TVTPVFATGP GGSESLKAYL KQAAPARGPT VRTKKVGKNE AVLAWDQIPV DDQNGFIRNY SISYRTSVGK |
Product Science Overview
Interleukin-6 (IL-6) is a multifunctional cytokine that plays a crucial role in immune response, inflammation, and hematopoiesis. The IL-6 receptor (IL-6R) is composed of two subunits: the IL-6 receptor alpha (IL-6Rα) and the signal-transducing component gp130 (also known as IL-6Rβ or CD130). The IL-6 receptor beta (IL-6Rβ) is essential for IL-6 signal transduction and is involved in various physiological and pathological processes.
The IL-6 receptor beta (mouse recombinant) is a single non-glycosylated polypeptide chain containing 187 amino acids . It signals through a cell-surface type I cytokine receptor complex consisting of the ligand-binding IL-6Rα chain and the signal-transducing component gp130 . The recombinant form of IL-6Rβ is produced using E. coli expression systems and is purified to high levels of purity for research purposes .
IL-6Rβ is a critical component of the IL-6 signaling pathway. Upon binding of IL-6 to IL-6Rα, the complex associates with gp130, leading to the activation of intracellular signaling cascades such as the JAK/STAT, MAPK, and PI3K/Akt pathways . These signaling pathways regulate various cellular processes, including cell proliferation, differentiation, and survival.
Recombinant IL-6Rβ is widely used in immunological research to study the molecular mechanisms of IL-6 signaling and its role in immune modulation . It is also utilized in the development of therapeutic strategies for diseases associated with dysregulated IL-6 signaling, such as autoimmune disorders, chronic inflammatory diseases, and certain cancers .
The recombinant mouse IL-6Rβ protein is typically lyophilized from a 0.2 μm filtered solution in sodium acetate and EDTA with trehalose and BSA as a carrier protein . It is reconstituted at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin . The product is shipped at ambient temperature and should be stored at -20 to -70 °C to maintain stability and bioactivity .
