IL 6 Antibody

Interleukin-6 (IL-6) is a multifunctional cytokine that plays a crucial role in the immune response, inflammation, and hematopoiesis . It is produced by various cell types, including T cells, B cells, macrophages, fibroblasts, and endothelial cells . IL-6 is involved in the transition between innate and adaptive immunity, helping to recruit immune cells to sites of infection or injury .

IL-6 is a small polypeptide with a molecular weight of 19–28 kDa, consisting of four α-helices . It is usually found in a monomeric form and comprises 184 amino acid residues, glycosylation sites, and two disulfide bonds . The IL-6 gene is located on chromosome 7p and includes four introns and five exons .

IL-6 has a wide range of biological activities, including:

• Regulation of immune responses: IL-6 stimulates the differentiation of B cells into antibody-producing plasma cells and promotes the proliferation of T cells .
• Acute phase response: IL-6 induces the production of acute-phase proteins in the liver, which play a role in inflammation and infection .
• Hematopoiesis: IL-6 supports the growth and differentiation of hematopoietic stem cells .
• Inflammation: IL-6 is involved in the inflammatory response by promoting the recruitment of immune cells to sites of infection or injury .

IL-6 is implicated in the pathogenesis of several autoimmune and inflammatory diseases, including rheumatoid arthritis (RA), juvenile idiopathic arthritis, giant cell arteritis, and cytokine release syndrome . Elevated levels of IL-6 are associated with chronic inflammation and tissue damage in these conditions .

Mouse anti-human IL-6 antibodies are monoclonal antibodies developed to specifically target and neutralize human IL-6 . These antibodies are produced by immunizing mice with human IL-6 and then isolating and cloning the antibody-producing B cells . The resulting monoclonal antibodies can bind to human IL-6 with high specificity and affinity, inhibiting its biological activity .

Mouse anti-human IL-6 antibodies have several important applications in research and therapy:

• Research: These antibodies are used in various experimental settings to study the role of IL-6 in immune responses, inflammation, and disease pathogenesis .
• Therapeutic potential: Anti-IL-6 antibodies have shown promise in the treatment of autoimmune and inflammatory diseases by blocking IL-6 signaling and reducing inflammation . For example, humanized anti-IL-6 antibodies like HZ-0408b have demonstrated efficacy in preclinical models of rheumatoid arthritis .