IL4I1 Human
IL-4I1, IL4I1, IL4-I1, IL4I-1
Greater than 90% as determined by SDS-PAGE.
Description
IL4R produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (26-232 a.a.) and fused to an 8 aa His Tag at C-terminus containing a total of 215 amino acids and having a molecular mass of 24.7kDa.
IL4R shows multiple bands between 28-40kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
Product Specs
IL-4I1, IL4I1, IL4-I1, IL4I-1
ADL QDWKAER SQDPFEKCMQ DPDYEQLLKV VTWGLNRTLK PQRVIVVGAG VAGLVAAKVL SDAGHKVTIL EADNRIGGRI FTYRDQNTGW IGELGAMRMP SSHRILHKLC QGLGLNLTKF TQYDKNTWTE VHEVKLRNYV VEKVPEKLGY ALRPQEKGHS PEDIYQMALN QALKDLKALG CRKAMKKFER HTLLEYLLGE GNLSRPAVQL LGDVMSEDGF FYLSFAEALR AHSCLSDRLQ YSRIVGGWDL LPRALLSSLS GLVLLNAPVV AMTQGPHDVH VQIETSPPAR NLKVLKADVV LLTASGPAVK RITFSPPLPR HMQEALRRLH YVPATKVFLS FRRPFWREEH IEGGHSNTDR PSRMIFYPPP REGALLLASY TWSDAAAAFA GLSREEALRL ALDDVAALHG PVVRQLWDGT GVVKRWAEDQ HSQGGFVVQP PALWQTEKDD WTVPYGRIYF AGEHTAYPHG WVETAVKSAL RAAIKINSRK GPASDTASPE GHASDMEGQG HVHGVASSPS HDLAKEEGSH PPVQGQLSLQNTTHTRTSH H HHHHHH
Product Science Overview
Interleukin-4 Induced-1 (IL4I1) is a protein encoded by the IL4I1 gene, which is induced by the cytokine interleukin-4 (IL-4) in B cells. This protein is also expressed in macrophages and dendritic cells. IL4I1 is a secreted L-amino acid oxidase that primarily catabolizes L-phenylalanine and, to a lesser extent, L-arginine . It plays a significant role in the immune system, particularly in immune regulation and tumor-associated macrophages .
IL4I1 belongs to the flavin monoamine oxidase family and contains domains involved in the binding of flavin adenine dinucleotide (FAD) cofactor . It has a preference for L-aromatic amino acids, converting phenylalanine, tyrosine, and tryptophan to phenylpyruvic acid, hydroxyphenylpyruvic acid, and indole-3-pyruvic acid, respectively . This protein is crucial in modulating T-cell responses and may play a role in immune system escape mechanisms in tumors .
The expression of IL4I1 is induced by IL-4 in B cells and is also found in macrophages and dendritic cells . It is highly expressed in primary mediastinal B-cell lymphomas and is involved in the immune response by suppressing T-cell activity . The gene encoding IL4I1 has multiple transcript variants encoding different isoforms, and some transcripts share a promoter and exons of the 5’ UTR with the overlapping NUP62 gene .
IL4I1 has been associated with various diseases, including striatonigral degeneration and primary mediastinal large B-cell lymphoma . Its role in immune regulation and tumor-associated macrophages suggests it may be involved in the immune system’s ability to evade detection and destruction by the body’s defenses . Additionally, IL4I1 has been implicated in the promotion of central nervous system remyelination, which is relevant in diseases like multiple sclerosis .
Recombinant human IL4I1 is produced using recombinant DNA technology, which involves inserting the IL4I1 gene into a suitable expression system, such as bacteria or mammalian cells, to produce the protein in large quantities . This recombinant protein is used in various research applications to study its function and role in disease processes .
