IL3RA Mouse
Interleukin 3 Receptor Subunit Alpha, Interleukin 3 Receptor, Alpha (Low Affinity), IL-3 Receptor Subunit Alpha, IL-3R Subunit Alpha, CD123 Antigen, IL-3R-Alpha, IL-3RA, IL3R, Interleukin-3 Receptor Subunit Alpha, IL-3 Receptor Alpha SP2 Isoform, HIL-3Ra, IL3RAY, CD123, IL3RX, IL3RY, IL3RA.
Greater than 90.0% as determined by SDS-PAGE.
Description
IL3RA Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (17-331 a.a.) and fused to a 231 a.a. Human IgG His Tag at C-terminus containing a total of 554 amino acids and having a molecular mass of 61.5 kDa.
Product Specs
Interleukin 3 Receptor Subunit Alpha, Interleukin 3 Receptor, Alpha (Low Affinity), IL-3 Receptor Subunit Alpha, IL-3R Subunit Alpha, CD123 Antigen, IL-3R-Alpha, IL-3RA, IL3R, Interleukin-3 Receptor Subunit Alpha, IL-3 Receptor Alpha SP2 Isoform, HIL-3Ra, IL3RAY, CD123, IL3RX, IL3RY, IL3RA.
SDLAAVREAP PTAVTTPIQN LHIDPAHYTL SWDPAPGADI TTGAFCRKGR DIFVWADPGL ARCSFQSLSL CHVTNFTVFL GKDRAVAGSI QFPPDDDGDH EAAAQDLRCW VHEGQLSCQW ERGPKATGDV HYRMFWRDVR LGPAHNRECP HYHSLDVNTA GPAPHGGHEG CTLDLDTVLG STPNSPDLVP QVTITVNGSG RAGPVPCMDN TVDLQRAEVL APPTLTVECN GSEAHARWVA RNRFHHGLLG YTLQVNQSSR SEPQEYNVSI PHFWVPNAGA ISFRVKSRSE VYPRKLSSWS EAWGLVCPPE VMPVK LEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGKHH HHHH
Product Science Overview
Interleukin-3 Receptor Subunit Alpha (IL-3Rα), also known as CD123, is a crucial component of the interleukin-3 (IL-3) receptor complex. This receptor plays a significant role in the regulation of hematopoiesis, the process by which blood cells are formed. The mouse recombinant version of IL-3Rα is widely used in research to study its function and potential therapeutic applications.
IL-3Rα is a protein encoded by the IL3RA gene. It is a ligand-specific alpha subunit of a heterodimeric cytokine receptor. The receptor complex is composed of IL-3Rα and a signal-transducing beta subunit, which is shared by the receptors for IL-3, colony-stimulating factor 2 (CSF2/GM-CSF), and interleukin-5 (IL-5) . The binding of IL-3 to IL-3Rα depends on the presence of the beta subunit, which is essential for the biological activities of IL-3 .
IL-3Rα is expressed on the surface of hematopoietic progenitor cells, monocytes, and B-lymphocytes. It controls the production and differentiation of these progenitor cells into lineage-restricted cells . The receptor is also expressed in various tissues, including the right uterine tube, cerebellum, ovary, lung, and bone marrow .
IL-3 is a hematopoietic growth factor that stimulates the formation of colonies of erythroid, megakaryocyte, neutrophil, eosinophil, basophil, mast cell, and monocytic lineages . The functions of IL-3 are often enhanced or dependent on co-stimulation with other cytokines . The activation of IL-3Rα leads to the phosphorylation and activation of effector proteins such as JAK2 and PI3K, which play a role in signaling cell proliferation and differentiation .
Recombinant mouse IL-3Rα is produced using various expression systems, including E. coli . This recombinant protein is used in research to study the signaling pathways and biological functions of IL-3. It is also used to investigate potential therapeutic applications, such as in the treatment of hematologic cancers and other diseases associated with dysregulated hematopoiesis .
