IL3RA Human
Interleukin 3 Receptor Subunit Alpha, Interleukin 3 Receptor, Alpha (Low Affinity), IL-3 Receptor Subunit Alpha, IL-3R Subunit Alpha, CD123 Antigen, IL-3R-Alpha, IL-3RA, IL3R, Interleukin-3 Receptor Subunit Alpha, IL-3 Receptor Alpha SP2 Isoform, HIL-3Ra, IL3RAY, CD123, IL3RX, IL3RY, IL3RA.
Greater than 90.0% as determined by SDS-PAGE.
Description
IL3RA produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (20-305 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 295 amino acids and having a molecular mass of 34.1kDa.
IL3RA is purified by proprietary chromatographic techniques.
Product Specs
Interleukin 3 Receptor Subunit Alpha, Interleukin 3 Receptor, Alpha (Low Affinity), IL-3 Receptor Subunit Alpha, IL-3R Subunit Alpha, CD123 Antigen, IL-3R-Alpha, IL-3RA, IL3R, Interleukin-3 Receptor Subunit Alpha, IL-3 Receptor Alpha SP2 Isoform, HIL-3Ra, IL3RAY, CD123, IL3RX, IL3RY, IL3RA.
ADLKEDPNPP ITNLRMKAKA QQLTWDLNRN VTDIECVKDA DYSMPAVNNS YCQFGAISLC EVTNYTVRVA NPPFSTWILF PENSGKPWAG AENLTCWIHD VDFLSCSWAV GPGAPADVQY DLYLNVANRR QQYECLHYKT DAQGTRIGCR FDDISRLSSG SQSSHILVRG RSAAFGIPCT
DKFVVFSQIE ILTPPNMTAK CNKTHSFMHW KMRSHFNRKF RYELQIQKRM QPVITEQVRD RTSFQLLNPG TYTVQIRARE RVYEFLSAWS TPQRFECDQE EGANTRAWRH HHHHH.
Product Science Overview
Interleukin-3 Receptor Subunit Alpha, also known as CD123, is a specific subunit of the interleukin-3 receptor. This receptor is a heterodimeric cytokine receptor composed of a ligand-specific alpha subunit and a signal-transducing beta subunit. The alpha subunit is crucial for binding interleukin-3 (IL-3), while the beta subunit is necessary for the biological activities of IL-3. The receptor is involved in the regulation of hematopoietic progenitor cells, monocytes, and B-lymphocytes, controlling their production and differentiation into lineage-restricted cells .
The gene encoding Interleukin-3 Receptor Subunit Alpha (IL3RA) is located in a cytokine receptor gene cluster in the X-Y pseudoautosomal region on chromosomes X or Y. The protein encoded by this gene is a cell surface receptor expressed on hematopoietic progenitor cells, monocytes, and B-lymphocytes . The receptor’s structure allows it to interact with IL-3, leading to the activation of various signaling pathways, including the JAK2-STAT5 pathway, which plays a role in cell proliferation and differentiation .
The primary function of Interleukin-3 Receptor Subunit Alpha is to mediate the effects of IL-3. Upon binding to IL-3, the receptor undergoes heterodimerization with the beta subunit, leading to the phosphorylation and activation of effector proteins such as JAK2 and PI3K. This activation triggers a cascade of signaling events that result in the proliferation and differentiation of hematopoietic progenitor cells .
Interleukin-3 Receptor Subunit Alpha is strongly expressed in various leukemic blasts and leukemic stem cells, making it an excellent target for leukemia therapy . The receptor’s role in hematopoiesis and its expression in leukemic cells have made it a focus of research for developing targeted therapies for hematologic cancers .
Recombinant human Interleukin-3 Receptor Subunit Alpha is produced using recombinant DNA technology. This involves inserting the gene encoding IL3RA into a suitable expression system, such as bacteria, yeast, or mammalian cells, to produce the protein in large quantities. The recombinant protein is then purified and used for various research and therapeutic applications .
