IL17RB Human

Interleukin-17 Receptor Beta Human Recombinant
Cat. No.
BT10277
Source

Sf9, Baculovirus cells.

Synonyms
Interleukin 17 Receptor B, IL17RH1, IL17BR, Interleukin 17B Receptor, Cytokine, Receptor-Like 4, Interleukin-17B Receptor, IL-17 Receptor Homolog 1, IL-17 Receptor B, IL-17B Receptor, IL-17Rh1, IL-17RB, EVI27, CRL4, Interleukin 17 Receptor Homolog 1, Interleukin-17 Receptor B, Cytokine Receptor CRL4.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
THE BioTeks products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

IL17RB Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 514 amino acids (18-292a.a) and having a molecular mass of 57.2kDa (Migrates at 50-70kDa on SDS-PAGE under reducing conditions).
IL17RB is fused to a 239 amino acid hIgG-His-tag at C-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
IL-17, a pro-inflammatory cytokine secreted by activated T cells, plays a crucial role in regulating immune responses. It modulates the activity of NF-kappaB and mitogen-activated protein kinases, influencing inflammatory signaling pathways. IL-17 stimulates the production of other inflammatory mediators like IL-6, cyclooxygenase-2 (COX-2), and nitric oxide (NO), amplifying the inflammatory cascade. Elevated IL-17 levels are implicated in various chronic inflammatory conditions such as rheumatoid arthritis, psoriasis, and multiple sclerosis, highlighting its significance in disease pathogenesis.
Description
Recombinant human IL17RB, expressed in Sf9 insect cells using a baculovirus system, is a single, glycosylated polypeptide chain. It consists of 514 amino acids, spanning residues 18-292a.a, and exhibits a molecular weight of 57.2 kDa. Notably, it migrates between 50-70 kDa on SDS-PAGE under reducing conditions due to glycosylation. The protein is engineered with a C-terminal 239 amino acid hIgG-His-tag to facilitate purification, which is achieved through proprietary chromatographic techniques.
Physical Appearance
Clear, colorless, and sterile-filtered solution.
Formulation
The IL17RB protein is supplied as a solution at a concentration of 0.25 mg/ml in a buffer comprising phosphate-buffered saline (pH 7.4) and 10% glycerol.
Stability
For short-term storage (up to 2-4 weeks), maintain the protein at 4°C. For extended periods, store frozen at -20°C. Adding a carrier protein like HSA or BSA (0.1%) is recommended for long-term storage to enhance stability. To preserve protein integrity, avoid repeated freeze-thaw cycles.
Purity
The purity of the IL17RB protein is greater than 85%, as determined by SDS-PAGE analysis.
Synonyms
Interleukin 17 Receptor B, IL17RH1, IL17BR, Interleukin 17B Receptor, Cytokine, Receptor-Like 4, Interleukin-17B Receptor, IL-17 Receptor Homolog 1, IL-17 Receptor B, IL-17B Receptor, IL-17Rh1, IL-17RB, EVI27, CRL4, Interleukin 17 Receptor Homolog 1, Interleukin-17 Receptor B, Cytokine Receptor CRL4.
Source

Sf9, Baculovirus cells.

Amino Acid Sequence
REPTVQCGSE TGPSPEWMLQ HDLIPGDLRD LRVEPVTTSV ATGDYSILMN VSWVLRADAS IRLLKATKIC VTGKSNFQSY SCVRCNYTEA FQTQTRPSGG KWTFSYIGFP VELNTVYFIG AHNIPNANMN EDGPSMSVNF TSPGCLDHIM KYKKKCVKAG SLWDPNITAC KKNEETVEVN FTTTPLGNRY MALIQHSTII GFSQVFEPHQ KKQTRASVVI PVTGDSEGAT VQLTPYFPTC GSDCIRHKGT VVLCPQTGVP FPLDNNKSKP GGWLPVEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGKHH HHHH.

Product Science Overview

Introduction

Interleukin-17 Receptor Beta (IL-17RB) is a crucial component of the immune system, playing a significant role in inflammatory and autoimmune responses. It is part of the larger interleukin-17 (IL-17) family, which includes six cytokines (IL-17A to IL-17F) that are involved in various immune functions .

Structure and Function

IL-17RB is a type I membrane glycoprotein that binds specifically to IL-17B and IL-17E (also known as IL-25). This receptor is characterized by a shared cytoplasmic motif known as the SEF/IL-17R (SEFIR) domain . The binding of IL-17B and IL-17E to IL-17RB triggers a cascade of signaling pathways that lead to the production of proinflammatory cytokines and chemokines .

Biological Significance

IL-17RB is expressed in various tissues, including the pancreas, small intestine, stomach, testis, spinal cord, prostate, colon, and ovary . Its expression is particularly strong in the pancreas and small intestine, suggesting a role in gastrointestinal and pancreatic functions .

Role in Disease

The IL-17RB pathway has been implicated in several diseases, particularly those involving inflammation and autoimmunity. For instance, IL-17RB is known to play a role in the pathogenesis of inflammatory bowel disease (IBD) and rheumatoid arthritis (RA). Additionally, recent studies have highlighted its involvement in cancer, where it may contribute to tumor growth and metastasis .

Therapeutic Potential

Given its role in various diseases, IL-17RB is considered a potential therapeutic target. Inhibitors of IL-17RB signaling are being explored as treatments for inflammatory and autoimmune diseases. Moreover, targeting IL-17RB may offer new avenues for cancer therapy .

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