IL 3 Antibody

Interleukin-3 (IL-3) is a cytokine that plays a crucial role in the immune system by regulating the production, differentiation, and function of various blood cells. It is a member of the β common chain family of cytokines, which also includes interleukin-5 (IL-5) and granulocyte-macrophage colony-stimulating factor (GM-CSF) . IL-3 is primarily produced by activated T cells, but it can also be produced by other immune cells such as monocytes, macrophages, and some non-immune cells like astrocytes and mesenchymal stem cells .

IL-3 exerts its function through a heterodimeric receptor composed of the IL-3 receptor α-chain (CD123) and the common receptor β-chain (CD131) . The α-chain (CD123) provides specificity for IL-3, while the β-chain (CD131) is essential for signaling and receptor assembly . In mice, there is an additional IL-3-specific β chain that shows strong homology with CD131 but differs in its ability to bind IL-3 directly . The interaction between IL-3 and its receptor leads to the activation of several downstream signaling pathways, including JAK2/STAT5, PI-3K/AKT, and MAPK .

IL-3 is involved in various biological processes, including:

• Hematopoiesis: IL-3 stimulates the proliferation and differentiation of hematopoietic stem and progenitor cells (HSPCs), leading to the production of various blood cell types .
• Immune Response: IL-3 plays a role in the immune response by regulating the function of immune cells such as basophils, eosinophils, mast cells, monocytes, macrophages, and dendritic cells .
• Inflammation: IL-3 can either promote or resolve inflammation depending on the type of disease, the course of inflammation, and the cells or tissues involved .

Mouse anti-human IL-3 antibodies are monoclonal antibodies produced in mice that specifically target human IL-3. These antibodies are used in various research and clinical applications to study the function of IL-3 and its role in different diseases. They can also be used to block the interaction between IL-3 and its receptor, thereby inhibiting IL-3-mediated signaling pathways .

Mouse anti-human IL-3 antibodies have several applications, including:

• Research: These antibodies are used in immunological research to study the role of IL-3 in various biological processes and diseases. They can be used in techniques such as flow cytometry, immunohistochemistry, and ELISA to detect and quantify IL-3 .
• Therapeutics: Targeting IL-3 or its receptor with monoclonal antibodies has potential therapeutic applications in treating diseases characterized by abnormal IL-3 activity, such as certain inflammatory and autoimmune disorders .