IgA Sec antibody

The IgA secretory component is a crucial part of the immune system, particularly in mucosal immunity. It is a single-chain glycoprotein synthesized by epithelial cells in mucous membranes and exocrine glands. This component is essential for the formation and function of secretory IgA (SIgA), which plays a significant role in protecting mucosal surfaces from pathogens.

The secretory component is a glycoprotein with a molecular weight of approximately 75,000 Daltons . It occurs both in a free form and as a subunit of the SIgA molecule. The secretory component is attached to the immunoglobulin molecule during the secretion process. Its primary functions include:

• Protection of IgA: It protects IgA against destruction by proteolysis.
• Transport of IgA: It facilitates the transport of IgA across the epithelial surface.
• Immune Response: It attracts circulating lymphocytes with surface IgA to mucous membranes .

Mouse anti-human IgA secretory component antibodies are monoclonal antibodies produced in mice. These antibodies are highly specific and are used in various scientific applications, including Western Blotting (WB), Immunohistochemistry (IHC), and Enzyme-Linked Immunosorbent Assay (ELISA) .

• Western Blotting (WB): Used to detect the presence of IgA secretory component in human samples.
• Immunohistochemistry (IHC): Used for the localization of the secretory component in mucous membrane tissues.
• ELISA: Used for the quantitative determination of human secretory component or SIgA in various body fluids .

High concentrations of SIgA or free secretory component are reported in patients with carcinomas and chronic infectious diseases . This makes the IgA secretory component a valuable marker in clinical diagnostics and research.