GRO b Mouse

GRO-Beta was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation . It is a member of the alpha (C-X-C) subfamily of chemokines, which are characterized by the presence of a conserved cysteine motif separated by a single amino acid .

The primary function of GRO-Beta is to act as a chemoattractant for neutrophils, guiding them to sites of inflammation or infection. It achieves this by binding to the CXCR2 receptor on the surface of neutrophils, which triggers a signaling cascade that results in the migration of these immune cells to the affected area . This process is essential for the body’s defense against infections and for the resolution of inflammation.

Recombinant GRO-Beta (Mouse) is produced using E. coli expression systems. The recombinant protein is typically purified to a high degree of purity (>95%) and is available in both carrier-free and carrier-containing formulations . The carrier protein, often Bovine Serum Albumin (BSA), enhances protein stability and shelf-life .

Recombinant GRO-Beta is widely used in research to study its role in immune responses and inflammation. It is also used in various assays to investigate the signaling pathways involved in chemokine-mediated cell migration and activation .

Recombinant GRO-Beta is typically lyophilized and can be stored at -20°C to -80°C for up to twelve months. Once reconstituted, it should be stored under sterile conditions and aliquoted to avoid repeated freeze-thaw cycles .