FKBP2 Human
Description
Product Specs
Product Science Overview
FK506 Binding Protein 2 (FKBP2), also known as FKBP13, is a member of the FK506-binding protein family. These proteins are peptidyl-prolyl cis-trans isomerases (PPIases) that play a crucial role in protein folding and immunoregulation. FKBP2 is particularly significant due to its involvement in various cellular processes, including protein folding within the endoplasmic reticulum (ER).
FKBP2 is characterized by its ability to bind to the immunosuppressive drugs FK506 (tacrolimus) and rapamycin. This binding inhibits the activity of calcineurin, a phosphatase involved in T-cell activation, thereby exerting immunosuppressive effects. FKBP2 contains a PPIase domain, which catalyzes the cis-trans isomerization of proline residues in polypeptides, facilitating proper protein folding.
Within the ER, FKBP2 assists in the folding of newly synthesized proteins. It is particularly involved in the folding of proinsulin, a precursor to insulin. FKBP2 interacts with proinsulin and its chaperone GRP94, ensuring correct folding and preventing the formation of misfolded protein complexes . This function is critical for maintaining cellular homeostasis and preventing ER stress.
The immunosuppressive properties of FKBP2 have therapeutic implications, particularly in organ transplantation and autoimmune diseases. By inhibiting calcineurin, FKBP2 helps prevent the rejection of transplanted organs and reduces the activity of the immune system in autoimmune conditions. Additionally, FKBP2’s role in protein folding makes it a potential target for treating diseases associated with protein misfolding and ER stress.
Recent studies have explored the broader implications of FKBP2 in various biological processes and diseases. For instance, FKBP2 has been implicated in the regulation of calcium signaling pathways through its interaction with ryanodine receptors . This interaction is crucial for maintaining calcium homeostasis in cells, which is essential for numerous physiological functions.
Moreover, FKBP2’s involvement in the Notch signaling pathway highlights its potential role in developmental processes and cancer . Understanding the molecular mechanisms of FKBP2 can lead to the development of novel therapeutic strategies targeting these pathways.
