ENO2 Protein
Enolase-2 Human
Cat. No.
BT16942
Source
Human CNS.
Synonyms
Gamma-enolase, EC 4.2.1.11, 2-phospho-D-glycerate hydro-lyase, Neural enolase, Neuron-specific enolase, NSE, Enolase 2, ENO2.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 96.0%.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
Human Neurone Specific Enolase produced in Human CNS having a molecular mass of 45kDa.
Product Specs
Introduction
Neuron-specific enolase (NSE), also known as Enolase-2, is a glycolytic isoenzyme primarily found in central and peripheral neurons and neuroendocrine cells. NSE is released into the cerebrospinal fluid (CSF) upon neural tissue injury. Additionally, neoplasms originating from neural or neuroendocrine tissue release NSE into the bloodstream. NSE serves as a valuable biomarker and has been detected in patients with various tumors, including neuroblastoma, small cell lung cancer, medullary thyroid cancer, carcinoid tumors, pancreatic endocrine tumors, and melanoma. ENO2 is one of the three enolase isoenzymes present in mammals. The ENO2 isoenzyme is specifically found in mature neurons and cells of neuronal origin. During development in rats and primates, a transition from alpha enolase to gamma enolase (NSE) occurs in neural tissue.
Description
Human Neuron Specific Enolase (NSE) is a protein with a molecular mass of 45 kDa, produced in the human central nervous system (CNS).
Physical Appearance
Clear solution that has been sterilized by filtration.
Formulation
The protein is dissolved in a solution of 10mM NaH2PO4 buffer at pH 7.4, containing 150mM NaCl and 5mM MgSO4.
Stability
While Human NSE remains stable at 4°C for up to 1 week, it is recommended to store the protein at -18°C for long-term storage.
Purity
The purity of the Human NSE protein is greater than 96.0%.
Synonyms
Gamma-enolase, EC 4.2.1.11, 2-phospho-D-glycerate hydro-lyase, Neural enolase, Neuron-specific enolase, NSE, Enolase 2, ENO2.
Source
Human CNS.
Product Science Overview
Structure and Function
Gamma-enolase is a phosphopyruvate hydratase that plays a crucial role in the glycolytic pathway. It catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate, a key step in glycolysis . This reaction is essential for the production of ATP, the primary energy currency of the cell .
In addition to its role in glycolysis, gamma-enolase has several other functions:
- Neuronal Survival and Differentiation: It is essential for the survival, differentiation, and maturation of neurons and glial cells in the central nervous system .
- Neuroprotection: Gamma-enolase exhibits neurotrophic-like properties, offering protection against neurotoxicity seen in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease .
- Biomarker: It serves as a critical biomarker for neurodegenerative pathologies and neurological conditions .
Expression and Regulation
Clinical Significance
Research and Therapeutic Potential
Research on gamma-enolase continues to uncover its multifunctional roles in the central nervous system. Its neuroprotective properties and involvement in neuronal survival make it a promising target for therapeutic interventions in neurodegenerative diseases . However, the effectiveness of enolase inhibitors as a therapeutic strategy is still under debate .
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