CD200 Human

CD200 contains two immunoglobulin domains and is involved in various biological processes, including the negative regulation of macrophage activation, regulation of immune response, and cell adhesion . The human CD200 cDNA encodes a 278 amino acid precursor, which includes a 30 amino acid signal sequence, a 202 amino acid extracellular domain, a 27 amino acid transmembrane segment, and a 19 amino acid cytoplasmic domain .

CD200 is expressed in various tissues, including the central nervous system, where it plays a role in neuroinflammatory responses . It is also found in other tissues such as the skin, lungs, and reproductive organs . The broad distribution of CD200 suggests its importance in maintaining immune tolerance and preventing excessive inflammatory responses.

Dysfunction or altered expression of CD200 has been associated with several diseases, including Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy . The regulatory role of CD200 in immune responses makes it a potential therapeutic target for treating autoimmune diseases and inflammatory conditions.

Recombinant human CD200 is produced using various expression systems, including HEK293 cells . The recombinant protein is often tagged with a His-tag for purification purposes and is used in research to study its interactions and functions . The recombinant form retains the biological activity of the native protein and is used in various assays to understand its role in immune regulation.