CD200 Mouse
Sf9, Baculovirus cells.
MOX1, MOX2, MRC, OX-2, OX-2 membrane glycoprotein, CD_antigen, CD200.
Description
CD200 Mouse Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 441 amino acids (31-232aa) and having a molecular mass of 49.5kDa.
CD200 is fused to a 239 amino acid hIgG-His-Tag at C-terminus and purified by proprietary chromatographic techniques.
Product Specs
MOX1, MOX2, MRC, OX-2, OX-2 membrane glycoprotein, CD_antigen, CD200.
Sf9, Baculovirus cells.
QVEVVTQDER KALHTTASLR CSLKTSQEPL IVTWQKKKAV SPENMVTYSK THGVVIQPAY KDRINVTELG LWNSSITFWN TTLEDEGCYM CLFNTFGSQK VSGTACLTLY VQPIVHLHYN YFEDHLNITC SATARPAPAI SWKGTGTGIE NSTESHFHSN GTTSVTSILR VKDPKTQVGK EVICQVLYLG NVIDYKQSLD KGLEHHHHHH.
Product Science Overview
CD200 is composed of one Ig-like V-type and one Ig-like C2-type domain in its extracellular region . The protein is expressed on a variety of cell types, including thymocytes, neurons, endothelial cells, and certain types of myeloid cells. Its primary function is to deliver inhibitory signals through its receptor, CD200R, which is predominantly expressed on myeloid cells such as macrophages and dendritic cells .
The interaction between CD200 and CD200R is essential for maintaining immune homeostasis. This interaction helps to suppress the activation of myeloid cells, thereby preventing excessive inflammatory responses and promoting immune tolerance . The CD200-CD200R axis has been implicated in various physiological and pathological processes, including autoimmunity, transplantation tolerance, and tumor immunity .
Recombinant mouse CD200 is produced using a mouse myeloma cell line, NS0-derived mouse CD200 protein. The recombinant protein is typically purified to a high degree of purity (>95%) and is used in various research applications, including functional assays and binding studies . The recombinant form of CD200 is often used to study its interaction with CD200R and to explore its potential therapeutic applications in modulating immune responses.
Recombinant CD200 has been utilized in numerous studies to understand its role in immune regulation. It has been used in functional ELISA assays to measure its binding ability to CD200R . Additionally, recombinant CD200 is employed in studies investigating its potential to modulate immune responses in various disease models, including autoimmune diseases, cancer, and infectious diseases .
