CD200R1 Mouse
Description
CD200R1 is expressed with a 239 amino acid hIgG His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
CD200R1, also referred to as cell surface glycoprotein CD200 receptor 1, represents an isoform of CD200 receptors found on cells of the myeloid lineage. The CD200R1 inhibitory signaling pathway plays a crucial role in suppressing inflammation across a wide array of inflammatory diseases. CD200R1 signaling inhibits the production of pro-inflammatory mediators such as tumor necrosis factor, interferons, and inducible nitric oxide synthase in response to specific stimuli.
Repeated freezing and thawing should be avoided.
Product Science Overview
CD200R1 is a 90 kDa protein that forms a disulfide-linked homodimer . The recombinant version of this protein, derived from mouse myeloma cell lines, is often used in research to study its function and interactions . The recombinant mouse CD200R1 protein typically includes the extracellular domain of the receptor, which is essential for its binding activity .
The primary function of CD200R1 is to interact with its ligand, CD200, which is expressed on a variety of cells, including neurons, endothelial cells, and lymphocytes . This interaction is crucial for maintaining immune homeostasis and preventing excessive inflammatory responses . By binding to CD200, CD200R1 transmits inhibitory signals that downregulate the activity of myeloid cells, thereby reducing inflammation and promoting immune tolerance .
Recombinant mouse CD200R1 is widely used in immunological research to study its role in immune regulation and its potential therapeutic applications . For instance, it is used in functional assays to measure its binding ability and to investigate the signaling pathways involved in its inhibitory effects . Additionally, it is utilized in the development of therapeutic strategies aimed at modulating immune responses in various diseases, including autoimmune disorders and cancer .
The recombinant mouse CD200R1 protein is produced in mouse myeloma cell lines and is purified to a high degree of purity, typically greater than 85% as determined by SDS-PAGE under reducing conditions . The protein is often formulated in a carrier-free form, which means it does not contain bovine serum albumin (BSA), making it suitable for applications where the presence of BSA could interfere .
