APOH Bovine
Greater than 70% as determined by SDS-PAGE.
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Description
Product Specs
Product Science Overview
Apolipoprotein-H is a glycoprotein with a molecular weight of approximately 70 kDa . It attaches to numerous negatively charged substances, such as phospholipids and dextran sulfate . This binding capability allows APOH to prevent the activation of the intrinsic blood coagulation cascade by attaching to phospholipids on the surface of damaged cells .
APOH is involved in regulating several biological processes, including:
- Blood Coagulation: By binding to phospholipids, APOH prevents the activation of the intrinsic blood coagulation pathway, thus playing a protective role in maintaining blood fluidity .
- Immune Response: APOH has been shown to have a protective effect in conditions like sepsis. In pediatric sepsis, for instance, APOH levels are significantly decreased in patients compared to healthy controls. The application of recombinant APOH protein has been found to lower mortality rates, mitigate organ injury, and suppress inflammation in experimental models .
Research into APOH has highlighted its potential therapeutic value. For example, in sepsis treatment, APOH has been shown to inhibit M1 polarization in macrophages by suppressing the toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) signaling pathway . This suggests that APOH could be a valuable target for therapeutic interventions in inflammatory and immune-related conditions.
