ANXA7 Human
Annexin A7 Human Recombinant
Cat. No.
BT20786
Source
Escherichia Coli.
Synonyms
Annexin A7, Annexin-7, Annexin VII, Synexin, ANXA7, ANX7, SNX.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
ANXA7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 490 amino acids (1-466 a.a.) and having a molecular mass of 52.9kDa.
ANXA7 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
ANXA7 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
Annexin VII, a member of the annexin family, is a calcium-dependent phospholipid binding protein. With a molecular weight of approximately 51 kDa, it features a unique, highly hydrophobic N-terminal domain (167 amino acids) and a conserved C-terminal region (299 amino acids) characterized by alternating hydrophobic and hydrophilic segments. Structural analysis suggests that Annexin VII, a membrane binding protein, possesses diverse properties such as voltage-sensitive calcium channel activity, ion selectivity, and membrane fusion.
Description
Recombinant Human ANXA7, expressed in E. coli, is a single, non-glycosylated polypeptide chain comprising 490 amino acids (1-466 a.a.) with a molecular weight of 52.9 kDa. It includes a 24 amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
A clear solution, sterilized by filtration.
Formulation
ANXA7 protein solution at a concentration of 0.25 mg/ml in a buffer consisting of 20mM Tris-HCl (pH 8.0), 150mM NaCl, 1mM DTT, and 40% glycerol.
Stability
For short-term storage (2-4 weeks), store at 4°C. For extended periods, store frozen at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity exceeds 85.0% as determined by SDS-PAGE analysis.
Synonyms
Annexin A7, Annexin-7, Annexin VII, Synexin, ANXA7, ANX7, SNX.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMSYPGY PPTGYPPFPG YPPAGQESSF PPSGQYPYPS GFPPMGGGAY PQVPSSGYPG AGGYPAPGGY PAPGGYPGAP QPGGAPSYPG VPPGQGFGVP PGGAGFSGYP QPPSQSYGGG PAQVPLPGGF PGGQMPSQYP GGQPTYPSQP ATVTQVTQGT IRPAANFDAI RDAEILRKAM KGFGTDEQAI VDVVANRSND QRQKIKAAFK TSYGKDLIKD LKSELSGNME ELILALFMPP TYYDAWSLRK AMQGAGTQER VLIEILCTRT NQEIREIVRC YQSEFGRDLE KDIRSDTSGH FERLLVSMCQ GNRDENQSIN HQMAQEDAQR LYQAGEGRLG TDESCFNMIL ATRSFPQLRA TMEAYSRMAN RDLLSSVSRE FSGYVESGLK TILQCALNRP AFFAERLYYA MKGAGTDDST LVRIVVTRSE IDLVQIKQMF AQMYQKTLGT MIAGDTSGDY RRLLLAIVGQ
Product Science Overview
Gene and Isoforms
Structure and Function
Annexin A7 has a unique, highly hydrophobic N-terminal domain and a conserved C-terminal region composed of alternating hydrophobic and hydrophilic segments . The protein is involved in various cellular processes, including membrane fusion, vesicle trafficking, and exocytotic secretion of catecholamines .
Biological Properties
Expression and Localization
Annexin A7 is expressed in various tissues, including red blood cells and platelets. In red blood cells, it is proposed to be a key component in the Ca²⁺-dependent vesicle release process, which might protect cells against attacks by complement components . In platelets, its loss leads to a slightly slower aggregation velocity, compensated by an increased number of platelets .
Recombinant Human Annexin A7
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