ANXA10 Human

Annexin A10 contains four Annexin repeats, which are characteristic of the Annexin family. These repeats form a tightly packed disc known as the annexin domain. The protein has a unique N-terminal domain followed by a homologous C-terminal core domain containing the phospholipid-binding sites . The molecular weight of human Annexin A10 is approximately 37 kDa .

Recombinant human Annexin A10 is typically expressed in E. coli and purified to a high degree of purity, often greater than 95% as determined by SDS-PAGE . The protein is usually provided as a lyophilized powder and can be reconstituted in a suitable buffer for experimental use .

Members of the Annexin family, including Annexin A10, are involved in the regulation of cellular growth and signal transduction pathways. They play a role in cytoskeletal interactions and phospholipase inhibition . Annexin A10, in particular, has been reported as a clinically relevant marker for predicting outcomes in both early and advanced stages of bladder cancer .

Lyophilized Annexin A10 is stable for up to 12 months when stored at -20 to -80°C. Once reconstituted, the protein solution can be stored at 4-8°C for 2-7 days or at -20°C for up to 3 months . It is important to avoid repeated freeze-thaw cycles to maintain the protein’s stability and functionality .

Recombinant Annexin A10 is used in various research applications, including studies on cellular growth regulation, signal transduction pathways, and cancer research. Its high purity and stability make it a valuable tool for biochemical and cellular assays .