ANXA11 Human
Description
ANXA11 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 525 amino acids (1-505) and having a molecular mass of 56.6 kDa.
The ANXA11 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Product Specs
MGSSHHHHHH SSGLVPRGSH MSYPGYPPPP GGYPPAAPGG GPWGGAAYPP PPSMPPIGLD NVATYAGQFN QDYLSGMAAN MSGTFGGANM PNLYPGAPGA GYPPVPPGGF GQPPSAQQPV PPYGMYPPPG NPPSRMPSY PPYPGAPVPG QPMPPPGQQP PGAYPGQPPV TYPGQPPVPL PGQQQPVPSY PGYPGSGTVT PAVPPTQFGS RGTITDAPGF DPLRDAEVLR KAMKGFGTDE QAIIDCLGSR SNKQRQQILL SFKTAYGKDL IKDLKSELSG NFEKTILALM KTPVLFDIYE IKEAIKGVGT DEACLIEILA SRSNEHIREL NRAYKAEFKK TLEEAIRSDT GHFQRLLIS LSQGNRDEST NVDMSLAQRD AQELYAAGEN RLGTDESKFN AVLCSRSRAH LVAVFNEYQR MTGRDIEKSI CREMSGDLEE GMLAVVKCLK NTPAFFAERL NKAMRGAGTK DRTLIRIMVS RSETDLLDIR SEYKRMYGKS LYHDISGDTS GDYRKILLKI CGGND.
Product Science Overview
Annexin A11, encoded by the ANXA11 gene, has unique N-terminal domains and conserved C-terminal domains. The C-terminal domains contain the calcium-dependent phospholipid-binding sites, which are essential for its function . The protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases .
Annexin A11 is involved in several biological processes, including:
- Cell Division: It plays a role in the regulation of cytokinesis, the final stage of cell division.
- Apoptosis: Annexin A11 is implicated in the regulation of programmed cell death, particularly in immune cells. Mutations in this protein can lead to resistance to apoptosis, contributing to diseases such as sarcoidosis .
- Membrane Trafficking: It is involved in the transport of vesicles within cells, particularly in processes like exocytosis .
Over-expression of Annexin A11 has been linked to apoptotic alterations in schizophrenia, suggesting its involvement in the pathomechanisms of this disorder . Additionally, genetic mutations in Annexin A11 have been associated with increased susceptibility to sarcoidosis, a condition characterized by the formation of granulomas in various organs .
Recombinant human Annexin A11 is produced using genetic engineering techniques. The ANXA11 gene is cloned into an expression vector, which is then introduced into a host cell (such as E. coli or yeast). The host cells express the protein, which is subsequently purified for research or therapeutic use .
Recombinant Annexin A11 is used in various research applications, including:
- Studying Protein-Protein Interactions: It helps in understanding how Annexin A11 interacts with other proteins, such as PDCD6 and ALG2 .
- Investigating Disease Mechanisms: Researchers use it to study its role in diseases like sarcoidosis and schizophrenia.
- Drug Development: It serves as a target for developing new therapeutic agents aimed at modulating its function in disease contexts.
