Adiponectin Human Recombinant HMW Rich produced in HEK cells is a single, glycosylated, polypeptide chain (19-244) containing a total of 226 amino acids, having a molecular mass of 24.6kDa (calculated). Human Acrp30 HMW Rich migrates on SDS-PAGE under non-reducing conditions at ~ 884 kDa.
Recombinant Human Adiponectin (HMW Rich), expressed in HEK cells, is a single-chain polypeptide comprising amino acids 19-244. This glycosylated protein has a molecular weight of 24.6 kDa (calculated) and consists of 226 amino acids. Under non-reducing conditions on SDS-PAGE, it migrates at approximately 884 kDa.
Adiponectin is a 244 amino acid protein that belongs to the soluble defense collagen superfamily. It has a collagen-like domain structurally homologous with collagen VIII and X and a complement factor C1q-like globular domain . The protein forms homotrimers, which are the building blocks for higher-order complexes found circulating in serum .
There are three main forms of adiponectin:
The HMW form is considered the most biologically active and is particularly important in mediating the insulin-sensitizing effects of adiponectin .
Human recombinant adiponectin (HMW rich) is produced in HEK293 cells and is a single, glycosylated polypeptide chain containing 226 amino acids, with a molecular mass of 24.6 kDa (calculated) . This recombinant form is designed to mimic the naturally occurring HMW adiponectin, making it valuable for research and therapeutic applications.
Physical Appearance and Formulation:
Solubility and Stability:
Adiponectin is involved in various physiological processes, including:
Due to its significant role in metabolic processes, adiponectin is a subject of extensive research. It is used in studies related to: