TROVE2 Human

TROVE Domain Family Member 2, also known as TROVE2, Ro60, or SSA2, is a protein encoded by the TROVE2 gene in humans. This protein is a member of the TROVE (Telomerase, Ro, Vault) domain family, which is primarily involved in RNA binding .

The TROVE2 gene is located on chromosome 1 and encodes a protein that is approximately 60 kDa in size . The protein contains a conserved TROVE domain, which is crucial for its RNA-binding activity. Additionally, it has a von Willebrand factor A (vWA) domain, which is involved in protein-protein interactions .

TROVE2 is an RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs . This binding activity is essential for stabilizing these RNAs and protecting them from degradation . TROVE2 also binds to endogenous Alu retroelements, which are induced by type I interferon and stimulate proinflammatory cytokine secretion .

TROVE2 is clinically significant due to its association with autoimmune diseases such as Systemic Lupus Erythematosus (SLE) and Sjögren’s Syndrome . Sera from patients with these conditions often contain antibodies that react with the TROVE2 protein, treating it as a foreign antigen . This autoimmune response can lead to various clinical symptoms and complications.

Human recombinant TROVE2 is used in various research applications, including studies on RNA stability, autoimmune diseases, and inflammatory responses . The recombinant protein is produced using advanced biotechnological methods to ensure its purity and functionality for experimental purposes .