TROVE2 His Human

The Human Recombinant TROVE2 is produced in Escherichia coli (E. coli) and is a single, non-glycosylated polypeptide chain with a molecular mass of approximately 60 kDa . The recombinant protein is fused with a 6 amino acid His-Tag at the C-terminus, which facilitates its purification through proprietary chromatographic techniques .

TROVE2, or Ro 60 kDa autoantigen, binds to Y RNAs and may stabilize these RNAs from degradation . This stabilization is crucial for the proper functioning of cellular processes. The protein is also known to be involved in autoimmune responses, as sera from patients with Systemic Lupus Erythematosus (SLE) often contain antibodies that react with the normal cellular SSA2 protein .

The recombinant TROVE2 protein is widely used in laboratory research, particularly in studies related to autoimmune diseases like SLE and Sjögren’s syndrome . It is also used in various biochemical assays to understand its interaction with RNA molecules and its role in cellular processes .

The recombinant TROVE2 protein, although stable at 4°C for three weeks, should be stored below -18°C to prevent degradation . It is essential to avoid freeze-thaw cycles to maintain its stability and functionality .

Prospec’s recombinant TROVE2 protein is intended for laboratory research use only and is not suitable for use as drugs, agricultural or pesticidal products, food additives, or household chemicals . Researchers must handle it with care and follow appropriate safety guidelines.