TROVE2 Bovine, Biotin
Bovine tissues.
60 kDa SS-A/Ro ribonucleoprotein, 60 kDa ribonucleoprotein Ro, RoRNP, 60 kDa Ro protein, Ro 60 kDa autoantigen, TROVE domain family member 2, Sjoegren syndrome type A antigen, SS-A, Sjoegren syndrome antigen A2, TROVE2, RO60, SSA2, RO-60.
Greater than 83.0% as determined by SDS-PAGE.
Description
TROVE2 is a biotinlyated natural protein having a molecular mass of 58kDa. TROVE2 is purified from bovine tissues by protein-chemical methods.
Product Specs
TROVE2, a biotinylated natural protein with a molecular weight of 58kDa, is derived from bovine tissues and purified using specialized protein-chemical techniques.
TROVE2 is provided in a buffer solution composed of 20mM HEPES (pH 8.0), 150mM NaCl, and 20% glycerol.
For short-term storage (up to 2-4 weeks), TROVE2 should be kept refrigerated at 4°C. For extended storage, it is recommended to freeze the product at -20°C. To maintain product integrity, it is crucial to minimize freeze-thaw cycles.
SDS-PAGE analysis indicates a purity level exceeding 83.0%.
60 kDa SS-A/Ro ribonucleoprotein, 60 kDa ribonucleoprotein Ro, RoRNP, 60 kDa Ro protein, Ro 60 kDa autoantigen, TROVE domain family member 2, Sjoegren syndrome type A antigen, SS-A, Sjoegren syndrome antigen A2, TROVE2, RO60, SSA2, RO-60.
Bovine tissues.
Product Science Overview
TROVE Domain Family Member 2 (TROVE2), also known as Ro60, is a significant protein within the TROVE domain family. This family is primarily involved in RNA binding and stabilization. TROVE2 is a human recombinant protein that is often biotinylated for various research applications.
TROVE2 is a single, non-glycosylated polypeptide chain with a molecular mass of approximately 60 kDa . It is produced in E. coli and can be tagged with biotin to facilitate its use in various biochemical assays . The biotinylation of TROVE2 allows for easy detection and purification using streptavidin-based methods.
The primary function of TROVE2 is to bind several small cytoplasmic RNA molecules known as Y RNAs . This binding helps stabilize these RNAs from degradation, playing a crucial role in maintaining cellular RNA integrity . TROVE2 is also involved in the immune response, as it is recognized by autoantibodies in patients with autoimmune diseases such as Sjögren’s syndrome and systemic lupus erythematosus (SLE) .
