TARC Mouse
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Description
The TARC Mouse is purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Thymus and Activation Regulated Chemokine (CCL17), also known as TARC, is a member of the CC chemokine family. It is a small cytokine that plays a crucial role in the immune system by mediating the migration of immune cells to sites of inflammation or injury. CCL17 is particularly significant in the context of allergic reactions and autoimmune diseases.
The CCL17 gene is located on chromosome 8 in mice . The protein encoded by this gene is a chemokine that displays chemotactic activity specifically for T lymphocytes, but not for monocytes or granulocytes . The protein binds to chemokine receptors CCR4 and CCR8, which are expressed on various immune cells .
CCL17 is constitutively expressed in the thymus and can be induced in several cell types upon activation . It is produced by antigen-presenting cells such as dendritic cells, macrophages, and monocytes . The expression of CCL17 is regulated by various cytokines and inflammatory signals, making it a key player in the immune response.
CCL17 plays a pivotal role in T cell development in the thymus as well as in the trafficking and activation of mature T cells . It is involved in the recruitment of Th2 cells and CLA+ CD4+ T cells, which are essential for the immune response in allergic diseases . CCL17 also mediates chemotaxis, the directed movement of cells towards higher concentrations of the chemokine, thereby facilitating the migration of immune cells to sites of inflammation .
CCL17 has been implicated in various diseases, particularly those involving the immune system. It plays a complex role in cancer, where it can attract T-regulatory cells, allowing some cancers to evade an immune response . Conversely, in other cancers such as melanoma, an increase in CCL17 is linked to improved outcomes . Additionally, CCL17 is associated with autoimmune and allergic diseases, including atopic dermatitis, allergic asthma, allergic rhinitis, and allergic contact dermatitis .
Recombinant CCL17 (Mouse) is a laboratory-produced version of the natural chemokine. It is used in research to study the functions and mechanisms of CCL17 in various biological processes and diseases. Recombinant proteins are typically produced using bacterial or mammalian expression systems, allowing for the generation of large quantities of the protein for experimental purposes.
