TARC Human, His
Description
TARC Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 92 amino acids (24-94 a.a.) and having a molecular mass of 10.3 kDa.
The TARC is fused to 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Product Specs
MGSSHHHHHH SSGLVPRGSH MARGTNVGRE CCLEYFKGAI PLRKLKTWYQ TSEDCSRDAI VFVTVQGRAI CSDPNNKRVK NAVKYLQSLE RS.
Product Science Overview
Thymus and Activation Regulated Chemokine (TARC), also known as CCL17, is a small cytokine belonging to the CC chemokine family. It plays a crucial role in the immune system by attracting T lymphocytes to sites of inflammation or disease. This article provides a detailed background on CCL17, its functions, and its significance in various biological processes.
CCL17 is encoded by the CCL17 gene located on chromosome 16 in humans . The protein is primarily produced in the thymus and by antigen-presenting cells such as dendritic cells, macrophages, and monocytes . The recombinant form of CCL17, often tagged with a His tag for purification purposes, is used in various research applications.
CCL17 functions as a chemokine, a type of cytokine that induces chemotaxis in T-helper cells . It binds to chemokine receptors CCR4 and CCR8, which are expressed on type 2 helper T cells, cutaneous lymphocyte skin-localizing T cells, and regulatory T cells . By binding to these receptors, CCL17 plays a significant role in T cell development in the thymus and in the trafficking and activation of mature T cells .
CCL17 is involved in various immune responses, including the recruitment of leukocytes to inflamed tissues . It is particularly associated with type 2 immune responses and has been linked to autoimmune and allergic diseases . Elevated levels of CCL17 are often observed in conditions such as allergic asthma and atopic dermatitis .
The clinical relevance of CCL17 extends to its role in cancer and eosinophilic disorders. In some cancers, CCL17 attracts T-regulatory cells, allowing the cancer to evade the immune response . However, in other cancers like melanoma, increased levels of CCL17 are associated with improved outcomes . Additionally, CCL17 is a key player in eosinophilic disorders, where it contributes to the recruitment of eosinophils to inflamed tissues .
Recombinant CCL17, often tagged with a His tag, is widely used in research to study its functions and interactions. The His tag facilitates the purification of the protein, making it easier to study its biochemical properties and interactions with other molecules.
