SNRPD2 Human
Small Nuclear Ribonucleoprotein Polypeptide D2 Human Recombinant
Cat. No.
BT1137
Source
Escherichia Coli.
Synonyms
Small nuclear ribonucleoprotein Sm D2, Sm-D2, snRNP core protein D2, SNRPD2, SNRPD1, SMD2.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
SNRPD2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 138 amino acids (1-118 a.a.) and having a molecular mass of 15.6kDa. The SNRPD2 is purified by proprietary chromatographic techniques.
Product Specs
Introduction
As a member of the small nuclear ribonucleoprotein core protein family, SNRPD2 plays a crucial role in pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. This protein is a vital component of small nuclear ribonucleoproteins (snRNPs), which form the spliceosome in eukaryotic cells.
Description
This product consists of recombinant human SNRPD2 protein with a 20 amino acid His tag fused at its N-terminus. Produced in E. coli, it exists as a single, non-glycosylated polypeptide chain with a molecular weight of 15.6 kDa. The protein encompasses 138 amino acids, including the 118 amino acids of SNRPD2 (1-118 a.a.). Purification is achieved through proprietary chromatographic techniques.
Physical Appearance
Clear, colorless, and sterile-filtered solution.
Formulation
The SNRPD2 solution is supplied in a buffer consisting of 20mM Tris-HCl (pH 8.0), 50% glycerol, 0.1M NaCl, and 1mM DTT.
Stability
For optimal storage, keep at 4°C if the entire vial will be used within 2-4 weeks. For long-term storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for extended storage. Avoid repeated freeze-thaw cycles.
Purity
The purity of this product exceeds 90.0% as assessed by SDS-PAGE analysis.
Synonyms
Small nuclear ribonucleoprotein Sm D2, Sm-D2, snRNP core protein D2, SNRPD2, SNRPD1, SMD2.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MSLLNKPKSE MTPEELQKRE EEEFNTGPLS VLTQSVKNNT QVLINCRNNK KLLGRVKAFD RHCNMVLENV KEMWTEVPKS GKGKKKSKPV NKDRYISKMF LRGDSVIVVL RNPLIAGK.
Product Science Overview
Gene and Protein Structure
Function
SNRPD2 is essential for the biogenesis of small nuclear ribonucleoproteins and the splicing of pre-mRNA . It is a core component of the spliceosomal U1, U2, U4, and U5 snRNPs, which are the building blocks of the spliceosome . The spliceosome is responsible for removing introns from pre-mRNA, a critical step in the maturation of messenger RNA (mRNA) molecules .
Biological Pathways
Clinical Significance
Interactions
Recombinant SNRPD2
Human recombinant SNRPD2 is produced using recombinant DNA technology, which involves inserting the SNRPD2 gene into a suitable expression system, such as bacteria or yeast, to produce the protein in large quantities. This recombinant protein is used in various research applications to study its function, interactions, and role in disease.
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