RARRES2 Human, Sf9

Retinoic Acid Receptor Responder 2 (RARRES2), also known as Chemerin, is a protein encoded by the RARRES2 gene. This gene is involved in various biological processes, including adipogenesis, metabolism, and inflammation. The protein is secreted and functions as an adipokine, playing a significant role in regulating adipocyte differentiation and metabolic functions .

RARRES2 expression is upregulated by the synthetic retinoid tazarotene and is found in a wide variety of tissues. The protein acts as a ligand for several receptors, including ChemR23 (CMKLR1), CMKLR2, and CCRL2, though it binds with varying affinities . It has both pro-inflammatory and anti-inflammatory properties, depending on the enzymatic cleavage it undergoes .

The human recombinant RARRES2 is produced in Sf9 Baculovirus cells. This method involves the use of a baculovirus expression system to produce a single, glycosylated polypeptide chain containing 146 amino acids, with a molecular mass of approximately 16.9 kDa . The recombinant protein is used in various research applications to study its function and role in different biological processes.

RARRES2 is involved in several key pathways, including the response to elevated platelet cytosolic Ca2+ levels. It regulates adipocyte differentiation and modulates the expression of genes involved in lipid and glucose metabolism . Additionally, it plays a role in angiogenesis, which is essential for the expansion of white adipose tissue .

Mutations or dysregulation of the RARRES2 gene have been associated with various diseases, including Schnitzler Syndrome and Psoriasis . The protein’s role in inflammation and metabolism makes it a potential target for therapeutic interventions in metabolic disorders and inflammatory diseases.